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    You are here: Home > Pharmacy > E > Estradiol
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    Drug Information
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    What is Estradiol?

    Estradiol is a naturally occurring female estrogen hormone that regulates many processes in the female body. When there is a drop in this or lack of it, Estradiol, a prescription drug helps in replacing this. This is used in HRT or Hormone Replacement Therapy.

    What does Estradiol treat?

    Estradiol is a female estrogen hormone that treats problems associated with lack of estrogen. Since estrogen controls many processes of the female body, a drop in it can create diverse problems ranging from mood swings to irregular periods. Usage of Estradiol alleviates menopause symptoms like vaginal dryness/itching, irregular periods, hot flashes, night sweats, and mood swings. It also helps in the prevention of bone fractures (osteoporosis) and reduces the risk of heart attacks. It may also be used in the treatment of certain types of cancer. The Estradiol vaginal cream is prescribed for vaginal atrophy linked to menopause. This medicine may also be used to treat other conditions suggested by your doctor.

    Dosage Instructions

    Follow the Estradiol dosage prescribed by your physician and/or as directed on the prescription drug label. The dosage could vary based on individual patient requirements. As directed by your physician, you can take this with or without food. Avoid smoking while taking Estradiol.

    Missed a dose?

    Take it immediately once you remember. In case, this time is closer to the next dosage, skip it and get back to the prescribed schedule. Never double the dose. 


    Don’t waste any time and seek immediate medical attention.

    Drug Interactions

    Drug interactions must be considered before starting to take any kind of drug. Drug interactions might happen either when Amoxycillin is taken along with another drug or with particular foods. To prevent any kind of negative interaction, make sure you inform your doctor of any drugs you are taking including OTCs, health supplements like vitamins, minerals, herbal medicine and so on which may increase the effect of Estradiol. Appraise your doctor of any medical conditions that you are suffering from and your family history of medical ailments.

    It may interact with: 

    • Amobarbital 
    • Carbamazepine
    •  Griseofulvin 
    • Nelfinavir 
    • Phenobarbital 
    •  Phenytoin 
    •  Primidone 
    •  Rifampin
    •  Ritonavir
    •  St John's Wort 
    •  Warfarin 

     It may also interact with barbiturates, anti-epileptic medicines, blood thinners and corticosteroids. The list above is not exhaustive and drugs other than those could also interact with Estradiol.

    Estradiol has been shown to significantly lower the hormone needed to produce breast milk and can slow breast milk production. It’s important to inform your doctor if you are breast-feeding. It’s important that you do not stop or start taking any medicine without the consent of your physician.

    Possible Side Effects

    Estradiol does not have any major side effects and if any, they are minor and temporary. In rare cases, there might be major side effects and immediate medical attention must be sought. Side effects cannot be anticipated in advance.

    Some of the side effects that might occur are breast pain, difference in sex drive, bleeding, back pain, abdominal pain, depression, fatigue and vaginal discharge. The rare side effects are vaginal yeast infection, nasal congestion, cough and chills. Estradiol may increase your risk of blood clots, stroke or heart attack. This is not an exhaustive list of all side effects.

    If any side effects increase or change, consult your physician immediately. Always follow the physician’s directions correctly.

    What to ask your doctor before you start on Estradiol

    • Can I take Estradiol along with other drugs?
    •  Are there certain foods, beverages and products to be avoided while on Estradiol?
    •  What is the dosage of Estradiol to be consumed?
    • How should I use Estradiol?
    •  How will Estradiol work in my body? 
    •  How can the drug interactions and side effects of Estradiol be minimized or completely avoided?


    The health and medical information that we have provided are meant to supplement and not substitute the advice of your physician, pharmacists or other health care professionals. This does not suggest that usage of Estradiol is safe, appropriate or effective for you. Always ensure that you take this or any other drug only after consulting your physician.


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    Ask or Reply Questions
    Posted By... IDMRx User | 2011-07-07
    I take vivelle dot td 0.1 mg twice weekly patches, how much and how often should I take estradiol for an equivalent dose? Reply
    Replied by Pharmacist @ IDM
    Hi, Estradiol is the hormone secretion drug so regarding the dosage for hormone secretion drugs I would suggest you to please get confirmation from your physician.
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