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    You are here: Home > European Drugs > P > Phosex
    Ask or Reply Questions
    Posted By... IDMRx User | 2013-04-15
    wat is the mechanism of action of phosexr Reply
    Replied by Pharmacist @ IDM
    Hi, Mechanism of Action of Phosex (Calcium Acetate) Calcium acetate/magnesium carbonate is taken orally together with the meal.[1] Calcium acetate and magnesium carbonate compounds bind phosphorus derived from food thereby forming indigestible phosphate salts in the intestine that are subsequently excreted with the faeces. The aim of the therapy is to reach a normal serum phosphorus level, i.e. between 0.81 - 1.45 mmol/l (2.5 - 4.5 mg/dl) Absorption: Mainly from the small intestine. 1,25-Dihydroxycholecalciferol (calcitriol), a metabolite of vit D, enhances absorption. Distribution: Crosses the placenta & distributes into breast milk. Excretion: Excess calcium is mainly excreted renally. Unabsorbed calcium is eliminated in the faeces, secreted in bile & pancreatic juice. Small amounts are lost in the sweat, skin, hair & nails.
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