Could This Kill Cancer?
When Hendrik Luesch invited me to Florida to go snorkeling, I didn’t expect to be wading through brackish muck in the Indian River Lagoon, a 156-mile-long estuary. I’m traveling aboard a 21-foot fishing boat with Luesch, a 40-year-old associate professor of medicinal chemistry at the University of Florida in Gainesville. The visibility sucks, like swimming through a vat of kombucha. Luesch drags his fingers through the water, gathering a wad of flotsam. He raises the specimen into the sunlight to get a better look at the slime, known as cyanobacteria.
Cyanobacteria live in every ocean and on every continent in both salt and fresh water. One species causes a rash known as swimmer’s itch; another blooms in lakes and reservoirs, expelling a neurotoxin that can be fatal to humans. “They produce this huge diversity of compounds that have never been identified,” says Luesch, who’s been studying them since 1997. Luesch has investigated cyanobacteria from around the world—Hawaii, Florida, Guam, Palau—and last year he made a startling discovery: a family of cyanobacteria called Symploca emits a toxin that attacks tumors. Luesch sprinkled Symploca extract on cultures of colon, bone, and breast-cancer cells, and they withered within hours, as though they’d been doused with Roundup; he did the same with healthy cells, and they survived virtually unscathed. Luesch christened the new compound “largazole” (the first batch came from algae near Key Largo), and has recently completed animal testing: in mice, largazole slowed the growth of cancerous colorectal tumors. He hopes to have an FDA-approved treatment on the market in about 10 years—the typical timeline to develop a new drug.
Mother Nature is a pharmacological factory. The cholesterol-lowering drug Lipitor is a cousin of red yeast rice. A species of periwinkle from Madagascar excretes a chemical for treating leukemia. Malaria is combated with quinine, originally from a rainforest tree. “About 60-plus percent of all drugs are natural products, modified natural products, or mimics of natural products,” says David Newman, chief of the natural products branch at the National Cancer Institute (NCI). On land, we’ve already mined most of the easy targets for these compounds. Marine environments, however, have been largely ignored.
Now, advances in technology are making it easier and increasingly profitable to hunt for drugs in the ocean. Marine bioprospectors, as they’re known, are scouring coral reefs, deep-sea trenches, and everything in between. Newman estimates that at least 30 research teams are experimenting with marine-derived compounds for treating cancer, neural degenerative diseases like Alzheimer’s and Parkinson’s, malaria, diabetes, depression, asthma, and other ailments.
Last year, Israeli scientists identified a sea sponge that contains an antibiotic for fighting a type of potentially deadly fungal infection; other researchers announced they’d found a substance in Red Sea coral that targets skin cancer. Trabectedin—a chemotherapy drug modeled after a chemical discovered in sea squirts—has been FDA approved. And just last week, the FDA also approved eribulin mesylate, a synthetic form of a substance derived from a sea sponge, to fight advanced breast cancer. About 15 more compounds are undergoing clinical trials, including an antipain medication with 100 times the potency of morphine but with no addictive potential. Luesch is experimenting with toxins—drawn from several species of cyanobacteria—on several types of cancer, including neuroblastoma, a childhood disease that attacks nerve cells. In July 2009, he launched a four-year, $1.2 million NCI-funded study, part of which entails largazole testing on mice. Cancer patients come next.
Nov 23, 2010