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    What is Pirfenidone used for?

    Pirfenidone is used to treat mild-to-moderate idiopathic pulmonary fibrosis (IPF) in adults. IPF is a chronic progressive lung disease of unknown cause, characterized by scarring or thickening of the lungs (fibrosis), which can result in reduced lung volume.

    Pirfenidone is an oral antifibrotic drug that may reduce the scarring in the lungs and decrease inflammation, thereby slowing the progression of the disease. Pirfenidone belongs to a group of medicines known as antifibrotic and anti-inflammatory agents.

    Pirfenidone may also be used to treat other conditions as determined by your doctor.

    What is the recommended dosage of Pirfenidone?

    The dosage of Pirfenidone prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.

    Take Pirfenidone tablet by mouth, with food. Taking Pirfenidone with food helps avoid getting dizziness, upset stomach, heartburn, nausea and vomiting.

    Swallow the Pirfenidone tablet whole with water.

    What if you miss a dose of Pirfenidone?

    If your physician has instructed or directed you to take Pirfenidone medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses to catch up for the missed dose.

    Inform your doctor if you miss to take Pirfenidone tablet for 14 days in a row. Your doctor may ask you to re-start the Pirfenidone therapy in increasing doses.

    What if you overdose on Pirfenidone?

    Any medication taken in excess can have serious consequences. If you suspect an overdose of Pirfenidone, seek medical attention immediately.

    What other drugs could interact with Pirfenidone?

    It may be noted that drugs other than those listed above may also interact with Pirfenidone.

    Pirfenidone can interact with the following types of medicines: seizure medications, oral contraceptives and rifamycins. Avoid consuming grapefruit juice as well. Make sure to inform your doctor if you are taking any of the above-mentioned medicines.

    Usually drug interactions may occur when certain drugs are taken together. Before you take a medication for a particular ailment, you should inform the health expert about intake of any prescription medications, over-the-counter products (non-prescription medications) and dietary supplements like vitamins, minerals and herbals, which may increase the effect of Pirfenidone. This information can help your doctor to warn you of any possible drug interactions.

    Do let your doctor know if you smoke, consume alcohol or caffeinated drinks, or use illegal drugs as these may interfere with the action of your medication. It is also important to tell your healthcare professional if you have any medical conditions or a family history of any medical problems. Do not start or stop using any medicine without consulting your doctor.

    What are the side effects of Pirfenidone?

    Like other medicines, Pirfenidone can cause some side effects. If they do occur, the side effects of Pirfenidone are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately.

    It is pertinent to note that side effects of Pirfenidone cannot be anticipated. If any side effects of Pirfenidone develop or change in intensity, the doctor should be informed as soon as possible.

    Pirfenidone can cause side effects such as nausea, vomiting, heartburn, tiredness, loss of appetite, weight loss, sensitivity to sunlight, gas, constipation, and dry skin. This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are taking Pirfenidone.

    What are the questions to ask your doctor before taking Pirfenidone?

    Is it possible for me to take Pirfenidone with other drugs?
    Should certain beverages, foods and other products be avoided when I take Pirfenidone?
    What are the possible drug interactions of Pirfenidone?
    How will Pirfenidone work in my body?
    How should Pirfenidone be taken?How to reduce the risk of Pirfenidone drug interactions and side effects?

    What other important information should you know about Pirfenidone?

    Before taking Pirfenidone tablets, make sure to tell your doctor if you have

    • liver disease
    • kidney disease (requiring dialysis).

    - Be sure to tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding.
    - Also, let your doctor know if you are allergic to Pirfenidone, or if you have ever had an allergic reaction to any other medicines.
    - Pirfenidone may cause dizziness. Do not drive, operate machinery, or do any activities that require alertness until you are certain you can perform such tasks safely.
    - Pirfenidone may make you become more sensitive to the sun. Avoid direct exposure to sunlight.
    - Avoid smoking while on treatment with Pirfenidone.


    The health and medical information provided here is intended to supplement and not substitute for the expertise and judgment of your physician, pharmacists or other health care professional. It should not be understood to indicate that the use of Pirfenidone is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.


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