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    What is Sorafenib used for?

    Sorafenib is an anticancer medication used to treat adults with advanced renal cell carcinoma (primary kidney cancer that has spread to other parts of the body), who have failed to respond to other therapies.

    A targeted therapy drug, Sorafenib is also indicated for the treatment of hepatocellular carcinoma (advanced liver cancer) that cannot be removed by surgery.

    Sorafenib is also prescribed for the treatment of differentiated thyroid carcinoma (a type of thyroid cancer) that is progressive and can no longer respond to radioactive iodine treatment.

    Sorafenib belongs to a class of drugs called multikinase inhibitors. Sorafenib works by slowing or stopping the growth of cancer cells. Also, Sorafenib blocks the cancer cells from forming new blood vessels within the tumor.

    Sorafenib may also be used to treat other conditions as determined by your doctor.

    What is the recommended dosage of Sorafenib?

    The dosage of Sorafenib prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.

    Sorafenib should be taken by mouth on an empty stomach. Swallow Sorafenib tablets with a glass of water (at least 1 hour before or two hours after a meal).

    What if you miss a dose of Sorafenib?

    If your physician has instructed or directed you to take Sorafenib medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember but no sooner than 2 hours since your last meal. If it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses to catch up for the missed dose.

    What if you overdose on Sorafenib?

    Any medication taken in excess can have serious consequences. If you suspect an overdose of Sorafenib, seek medical attention immediately.

    Overdose symptoms of Sorafenib may include severe skin rash or severe diarrhea.

    What other drug(s) could interact with Sorafenib?

    It may be noted that drugs other than those listed above may also interact with Sorafenib. Make sure to inform your doctor if you are taking any of the above-mentioned medicines.

    Sorafenib can interact with the following types of medicines: other anticancer medicines, blood thinners, rifamycins, seizure medicines, heart medications, barbiturates, tuberculosis medications and HIV medicines.

    Usually drug interactions may occur when certain drugs are taken together. Before you take a medication for a particular ailment, you should inform the health expert about intake of any prescription medications, over-the-counter products (non-prescription medications) and dietary supplements like vitamins, minerals and herbals, which may increase the effect of Sorafenib. This information can help your doctor to warn you of any possible drug interactions.

    Do let your doctor know if you smoke, consume alcohol or caffeinated drinks, or use illegal drugs as these may interfere with the action of your medication. It is also important to tell your healthcare professional if you have any medical conditions or a family history of any medical problems. Do not start or stop using any medicine without consulting your doctor.

    What are the side effects of Sorafenib?

    Like other medicines, Sorafenib can cause some side effects. If they do occur, the side effects of Sorafenib are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately.

    It is pertinent to note that side effects of Sorafenib cannot be anticipated. If any side effects of Sorafenib develop or change in intensity, the doctor should be informed as soon as possible.

    Sorafenib can cause side effects such as diarrhea, nausea, loss of appetite, weight loss, fatigue, sore mouth, hoarseness, dry mouth, acne, hair thinning, high blood pressure, abdominal pain and hand–foot skin reaction (redness/pain/swelling/blistering on the palms or soles of your feet). This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are taking Sorafenib.

    What are the questions to ask your doctor before taking Sorafenib?

    Is it possible for me to take Sorafenib with other drugs?
    Should certain beverages, foods and other products be avoided when I take Sorafenib?
    What are the possible drug interactions of Sorafenib?
    How will Sorafenib work in my body?
    How should Sorafenib be taken?
    How to reduce the risk of Sorafenib drug interactions and side effects?

    What other important information should you know about Sorafenib?

    Before taking Sorafenib, make sure to tell your doctor if you

    • have heart problems
    • have bleeding disorder
    • have high blood pressure
    • have kidney or liver problems
    • have had a surgery recently or plan to have any surgical procedures
    • are pregnant, plan to become pregnant, or are breast-feeding.

    - Avoid becoming pregnant when taking Sorafenib.
    - Breastfeeding is not recommended while on treatment with Sorafenib.
    - Do not receive any immunization/vaccination without your doctor’s consent while taking Sorafenib tablets.
    - Also, let your doctor know if you are allergic to Sorafenib, or if you have ever had an allergic reaction to any other medicines.
    - Avoid contact with your body fluids (including vomit, urine, feces, vaginal fluid, semen).


    The health and medical information provided here is intended to supplement and not substitute for the expertise and judgment of your physician, pharmacists or other health care professional. It should not be understood to indicate that the use of Sorafenib is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.


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