Adapalene Clindamycin 0.1%/1% Gel 20g Glenmark
Adapalene Clindamycin 0.1%/1% Gel is a topical combination medication formulated with two active ingredients Adapalene, a retinoid, and Clindamycin, an antibiotic. This product is marketed internationally under names such as Differin and Adapalene-Clindamycin, and is available in India as Deriva-C Gel. It is manufactured by Glenmark and supplied in a convenient 20g tube for topical (skin) use.
What is Adapalene Clindamycin Gel used for?
This combination gel is used in the treatment of acne. Adapalene helps normalize skin cell turnover, while Clindamycin works against the bacteria associated with acne breakouts. Combining a retinoid with a topical antibiotic is a common approach in dermatology for managing acne lesions.
Your doctor or dermatologist will determine whether this specific combination and strength (0.1% Adapalene / 1% Clindamycin) is appropriate for your skin type and the severity of your condition.
Key Product Details
Product name: Adapalene Clindamycin 0.1%/1% Gel 20g
Generic/Active ingredients: Adapalene and Clindamycin
Strength: 0.1%–1%
Pack size: 20g tube
Drug type: Topical gel, supplied in tubes
Manufacturer: Glenmark
US brand names: Adapalene-Clindamycin, Differin
Indian brand name: Deriva-C Gel 20gm
Category: Acne treatment
How should this gel be used?
Adapalene Clindamycin Gel is intended for external use on the skin only. Always follow the instructions given by your prescribing doctor or the guidance printed on the product label/package insert regarding:
The amount of gel to apply
How often to apply it
Which areas of the skin to treat
How long the treatment course should continue
Do not use more of this medication, or use it more frequently, than directed, as this will not speed up results and may increase the risk of skin irritation. If you are unsure about the correct way to use this product, consult your doctor or pharmacist before starting treatment.
Precautions and Safety Information
Before using Adapalene Clindamycin Gel, discuss your complete medical history with your doctor, including:
Any known allergies to retinoids, antibiotics, or other ingredients in this product
Any current skin conditions, infections, or sensitivities
Other topical or oral medications, including over-the-counter skin products, that you are currently using
Whether you are pregnant, planning to become pregnant, or breastfeeding
General precautions that are often advised with topical acne treatments include:
Avoiding contact with the eyes, lips, and mucous membranes
Avoiding application to broken, sunburned, or irritated skin
Limiting excessive sun exposure and using sun protection, as retinoid-based products can increase skin sensitivity to sunlight
Avoiding use of other harsh or irritating skin products at the same time unless approved by your doctor
This is general guidance only. Please consult your doctor or pharmacist for precautions specific to your health condition and skin type before beginning treatment.
Possible Side Effects
As with any medication, some individuals may experience side effects while using this gel. Because specific side effect data for this product has not been provided, you should refer to the product package insert or speak with your pharmacist or doctor for a complete list of possible reactions. If you notice unusual skin irritation, redness, burning, peeling, or any other unexpected reaction after applying this product, discontinue use and contact your healthcare provider promptly.
Drug Interactions
Specific drug interaction data for this combination product has not been provided here. To avoid potential interactions with other topical or oral medications, supplements, or skincare products, always inform your doctor or pharmacist of everything you are currently using before starting this treatment.
Overdose and Missed Dose
If you accidentally apply more than the recommended amount, or if the gel is ingested or comes into contact with sensitive areas, contact your doctor or a poison control resource immediately. If you miss an application, follow the guidance provided by your doctor or the product label; do not apply extra gel to make up for a missed application.
Storage Instructions
Store the tube as directed on the packaging, generally in a cool, dry place away from direct sunlight and out of reach of children. Always check the expiration date before use and dispose of any unused or expired product according to local guidelines.
Frequently Asked Questions
How does Adapalene Clindamycin Gel work on acne?
Adapalene Clindamycin Gel combines two ingredients that tackle acne differently. Adapalene, a retinoid, helps normalize skin cell turnover and keeps pores from becoming clogged. Clindamycin, a topical antibiotic, works against the bacteria associated with acne breakouts. Together, they address more than one factor behind acne lesions. Your dermatologist will decide whether this combination and strength suit your skin type and the severity of your acne.
Can I buy it without a prescription?
This is a prescription-strength combination product, so it should be used only under the guidance of a licensed healthcare provider. A doctor can confirm whether it is appropriate for your condition, explain how much to apply and for how long, and monitor your progress. Please avoid self-medicating or sharing the tube with others, as suitability differs from person to person based on individual medical history.
Is it the same as Differin?
Not exactly. Differin is a brand of adapalene alone, whereas this product combines adapalene with clindamycin. In India, the Glenmark combination is sold as Deriva-C Gel. Brand names and formulations vary by region, so check the label for active ingredients and strength. If unsure whether a product matches what your doctor prescribed, ask your pharmacist before switching, since similar-sounding names can sometimes contain different ingredients.
How should I apply the gel?
Use it on the skin only, exactly as your doctor or the package insert directs regarding amount, frequency, treatment areas, and course length. Avoid contact with the eyes, lips, and mucous membranes, and do not apply to broken, sunburned, or irritated skin. Using more gel or applying it more often will not speed up results and may increase irritation, so follow directions carefully every time.
Do I need sun protection while using it?
Yes, sun protection is generally advised. Retinoid-based products such as adapalene can make skin more sensitive to sunlight, so limit excessive sun exposure and use sun protection while treating acne. Avoid combining the gel with other harsh or irritating skin products unless your doctor approves. If you notice burning, redness, or peeling, stop using it and contact your healthcare provider promptly for further medical advice.
Can I use it during pregnancy or breastfeeding?
Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding before starting this gel. Your doctor can weigh the benefits and risks for your situation and advise whether it is suitable or if an alternative is better. Also share any allergies to retinoids or antibiotics, and list all other medicines and skincare products you use, so potential interactions can be safely avoided.
Disclaimer: This description is intended for general informational purposes only and does not replace professional medical advice. Always consult your doctor or pharmacist before starting, stopping, or changing any medication, including this topical gel. Individual results, side effects, and interactions can vary, and only a licensed healthcare provider can determine if this product is suitable for your specific condition.
Reference
Differin UK SmPC (electronic Medicines Compendium):
Differin South Africa professional information
