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What is Agomelatine used for?

Agomelatine is prescribed for the treatment of major episodes of depression in adults. This medicine is also used to help prevent the relapse of depression. The common symptoms of depression can include sadness, loss of interest in social activities, anxiety, sleep problems and changes in appetite and weight. Agomelatine helps regulate the disturbances in sleep and appetite patterns caused by depression. This medicine may also be used to treat other conditions as determined by your doctor.

Agomelatine works by acting on melatonin and serotonin receptors in the brain. Also, by increasing certain natural chemicals, dopamine and noradrenaline, in the brain, Agomelatine helps improve mood and other symptoms of depression. Agomelatine belongs to a class of medicines called antidepressants.

What is the recommended dosage of Agomelatine?

The dosage of Agomelatine prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.

Agomelatine can be taken either with or without food.

What if you miss a dose of Agomelatine?

If your physician has instructed or directed you to take Agomelatine medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses to catch up for the missed dose.

What if you overdose on Agomelatine?

Any medication taken in excess can have serious consequences. If you suspect an overdose of Agomelatine, seek medical attention immediately. Overdose symptoms of Agomelatine may include dizziness, drowsiness, fatigue and anxiety.

What other drugs could interact with Agomelatine?

It may be noted that drugs other than those listed above may also interact with Agomelatine.

Agomelatine can interact with the following types of medicines: estrogens, certain antibiotics and antidepressants.

Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications (over-the-counter products) and dietary supplements like vitamins, minerals and herbal, which may increase the effect of Agomelatine, so that the doctor can warn you of any possible drug interactions.

Do let your doctor know if you smoke, consume alcohol or caffeinated drinks, or use illegal drugs as these may interfere with the action of your medication. Make sure to inform your doctor of any medical conditions you may have, or any family history of medical problems. Do not start or stop using any medicine without consulting your doctor.

What are the side effects of Agomelatine?

Like other medicines, Agomelatine can cause some side effects. If they do occur, the side effects of Agomelatine are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately.

It is pertinent to note that side effects of Agomelatine cannot be anticipated. If any side effects of Agomelatine develop or change in intensity, the doctor should be informed as soon as possible.

Agomelatine can cause side effects such as dizziness, headache, abdominal pain, constipation, diarrhea, insomnia, back pain, fatigue and increased sweating. This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are taking Agomelatine.

What are the questions to ask your doctor before taking Agomelatine?

Is it possible for me to take Agomelatine with other drugs?
Should certain beverages, foods and other products be avoided when I take Agomelatine?
What are the possible drug interactions of Agomelatine?
How will Agomelatine work in my body?
How should Agomelatine be taken?
How to reduce the risk of Agomelatine drug interactions and side effects?


The health and medical information provided here is intended to supplement and not substitute for the expertise and judgment of your physician, pharmacists or other health care professional. It should not be understood to indicate that the use of Agomelatine is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.

Avoid drinking alcohol while taking Agomelatine. This medicine is not recommended for children and adolescents under 18 years of age.


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