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Women who have attained menopause are likely to notice a few signs of this condition; typical signs include dryness of the vagina, hot flashes, etc. Most of these are triggered as your body makes lesser amount of a hormone called estrogen. Estradiol is a supplementary form of estrogen. This drug is administered onto women to manage the effects of menopause as well as to minimise adverse effects on bone health. But, do you kn0ow the best time to take estradiol pills? You are advised to know more in this regard before taking these pills.

Drugs are available that can help supplement the reduced availability of estrogen – a female sex hormone. Some of these meds also help prevent the incidence of bone losses – a condition called osteoporosis among women; especially, among those who have reached menopause. One such med is estradiol. This drug is available as multiple options namely, oral pills, a skin patch, gel, vaginal ointment as well as an injectable form.

As an extended use, doctors prescribe this med to treat hormonal imbalance (especially due to lack of needful estrogen) among women with an ovarian condition. In the same light, you need to know that estradiol may also be used for treating a few other clinical conditions i.e., those which are not listed above.

Best time to take estradiol pills – morning or night?

In general, it does not matter if you take these pills in the morning or evening. But, to enhance the efficacy of these pills – it is a good practice to take at the same time each day. At the starting stages, dosage strength ranges between 0.5 milligram (mg) to 1.5 mg, taken as a single dose within a 24-hour timeline.

The external release (ER) variant of estradiol is available as a cream (transdermal) – starting dose is 0.03 mg to 0.05 mg per day; this cream is applied two times each week. Your caregiver may vary the dosages based on responses to above dosage plan. On a maintenance mode, dosages can range from 0.03 to 0.75 mg – applied once per week.

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Foods to avoid while taking estradiol

You are advised not to consume grapefruit or grapefruit juice. As a safety measure, it is considered safe to avoid all forms of products made of grapefruit. You are also not advised to use tobacco – in any of its forms i.e., smoking, chewable, etc.

Also, those who smoked or used tobacco while taking estradiol are more likely to develop blood-clots, hypertension (elevated blood pressure), cardiac arrest and / or strokes. These pills must never be used while you are pregnant / planning to get pregnant. Those who became pregnant while using it must consult with their doctor on top priority basis.

You need to know estradiol pills are administered at the least possible dosage strength, for shortest timeline. Your caregiver will assess the outcomes by testing for hormonal levels on a periodic basis. If you observe a few adverse side effects like mood shifts, disturbed sleep, itchiness, abdominal discomforts like cramping, vomiting and nausea, you need to consult with your doctor quickly.

Those who witness signs of a blood-clot (pain in chest), coughing-up blood, gasping, etc.: you need to seek clinical support on an urgent basis. In such instances, users of estradiol in US must call 911 without delay; you can also dial helpdesk of food and drug administration (FDA).

FDA offers timely help to users of drugs to ensure patient-safety and to track adverse effects of meds the nodal agency approves. On the other hand, users of estradiol in Canada are advised to reach a poison control unit.

Lastly, to have more details about safe use of estradiol pills, it is a safe thing to consult with your treating physician and / or pharmacist.


Information provided here are only of supplementary nature. Information shared here does not substitute a qualified doctor’s advice. This website is not suggesting intake of this drug as safe or appropriate. Hence it is advised to talk to your doctor before consuming this med or any other drug.

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