Vyvanse drug test image

Vyvanse is one among the various medications presently prescribed to treat ADHD (attention deficit hyperactivity disorder). Belonging to the category of central nervous system stimulants, the medication works by increasing the levels of dopamine and norepinephrine in the brain. Consequently, this brings about increased focus, attention, impulse control, and hyperactivity. Certain substances are controlled substances, mainly due to the potential for abuse and the classification of drugs as stimulants. Following subsections offer a detailed look at the drug, along with answers to the question – Does Vyvanse (lisdexamfetamine) show up on a drug test?.

Overview of Vyvanse

Known by its generic name lisdexamfetamine, it is typically taken orally as a capsule, and the contents are absorbed in the gastrointestinal tract, following which it is converted into its active form, dextroamphetamine, in the blood. The extended-release medication, offers a gradual, sustained release of the active ingredient, over a longer period of time compared to immediate-release stimulant medications. The prescription medication is available in various strengths, and dosing and intake schedule depend on the individual’s age, weight, severity of symptoms, and response to the medication.

Average dosage of Vyvanse

As mentioned above, the dosage is determined by the treating specialist. The following information is only intended as a reference and is not a substitute for medical advice. Available in strengths of 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, and 60 mg capsules, Vyvanse is taken once daily in the morning either with food or without food. The starting dosage for Vyvanse in children above 6 years and adults is typically 30 mg once daily.  While the dosage may differ and be adjusted accordingly, the maximum recommended daily dose of Vyvanse for ADHD usually does not exceed 70 mg.

Mechanism of action of lisdexamfetamine

As a prodrug, Vyvanse is converted into its active form, dextroamphetamine, in the bloodstream. Dextroamphetamine is a central nervous system stimulant that increases the levels of dopamine and norepinephrine in the brain. This enhancement occurs at the nerve terminals in the brain, and the drug also inhibits reuptake, resulting in increased concentrations of the neurotransmitters. This, in turn enhances the activity of certain regions of the brain responsible for attention, impulse control, and hyperactivity.

Vyvanse is also known to have effects on other neurotransmitters – serotonin and glutamate.  The drug’s effects on neurotransmitters and brain function are complex and can vary depending on individual factors. This is one of the reasons for use under the supervision of a qualified healthcare professional as per prescribed dosage and instructions.

Side effects of Vyvanse

Commonly reported side effects of Vyvanse may include the following:

Drug interactions of Vyvanse  

In addition to the above, there is also the possibility of drug interactions, as listed below:

Does Vyvanse show up on a drug test?

Yes, lisdexamfetamine can show up on certain types of drug tests. The drug is a Schedule II controlled substance as per the classification of the Drug Enforcement Administration due to its potential for abuse and diversion. It is often listed in drug screening panels that test for amphetamine or stimulant use.

Standard urine drug tests typically do not specifically test for lisdexamfetamine, but can detect amphetamines. Post ingestion, lisdexamfetamine is metabolized in the body to dextroamphetamine, the active ingredient. Dextroamphetamine can be detected in urine for up to 1-2 days after intake of Vyvanse, depending on various factors such as the dosage, frequency of use, individual metabolism, and the specific type of drug test being used.

Vyvanse when prescribed by a healthcare professional is not illicit use and is also not a violation of drug testing policies in legitimate medical settings.

is Vyvanse part of the banned substances on doping list

Vyvanse is listed as a banned substance by the World Anti-Doping Agency (WADA), the nodal agency that establishes the anti-doping rules and regulations followed by international sports organizations and events. Vyvanse is classified as a stimulant and is prohibited both in-competition and out-of-competition in sports governed by WADA rules. Athletes governed by WADA regulations, need to be aware that Vyvanse is considered a banned substance and may result in anti-doping rule violations if detected.

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