Doxycycline monohydrate vs hyclate

Infections bacteria cause can bring down your productivity levels. Infections can include skin problems like acne; lung-related infections like pneumonia, rosacea, etc. Fortunately, drugs are widely available for treating most conditions bacteria triggers. These meds are labelled as antibiotics. Doxycycline monohydrate and doxycycline hyclate are commonly used antibiotic meds. But, do you know the differences between these 2 meds? It pays to know the key differences, especially prior to starting your medication plan.

Antibiotic meds are medications used for stopping the spread of infections caused by bacteria. But these drugs are essentially used for fighting bacteria and may not be effective against virus or yeast / fungus. Caveat: when you take these drugs without an underlying infection, it is likely to result in building resistance among microbes.

What is doxycycline hyclate?

This antibiotic belongs to sub-category called tetracycline genre. It is taken for treating different forms infections including anthrax, malaria, skin conditions such as inflammation, redness, bumps, rosacea and acne. It is important to continue this drug till your infection gets over. An abrupt discontinuation of doxycycline hyclate may lead to a relapse of infections.

What is doxycycline monohydrate?
This is also an antibiotic drug belonging to the tetracycline sub-genre. It is made with a few ingredients to prevent the sustenance of bacteria. This is possible by inhibiting some proteins that bacteria need to live. This med is used for a range of infections like urinary tract-related infections, (UTI), sexually transmitted conditions like syphilis, gonorrhea as well as chlamydia.

What are the differences between doxycycline and doxycycline hyclate?

Both these meds belong to the same class of drugs called tetracycline antibiotics. One of the major differences between these two drugs lies in their salt-form; else, most of the other aspects of these meds are largely the same. Doxycycline hyclate is available in both capsule and tablet forms; on the other hand, doxycycline monohydrate is available as a liquid suspension as well.

Popular brands names of doxycycline monohydrate include monodax, vibramycin, avidoxy, etc. Brands based on doxycycline hyclate include acticlate, targadox, doryx, etc. As both these drugs may make you sensitive to sunlight; hence, you are not advised to step out of your home without wearing a sunscreen lotion or cream.

Both these antibiotics i.e., doxycycline hyclate and doxycycline monohydrate may cause a few adverse side effects; these include sore throat, being dehydrated, painful spells of urination, diarrhea, nausea and / or vomiting. Some users of either of these meds have reported severe problems like blurred vision, bleeding internally, joint problems, inflammation and redness of skin. Upon sensing any of these side effects triggered by doxycycline hyclate or doxycycline monohydrate, you are advised to seek medical assistance from your physician on a top priority basis.

Those living in US may reach out to 911 or can also dial the helpdesk of the food and drug administration (FDA) – the federal drug clearing agency. If you are living in any of the Canadian provinces, rush to a local poison control department; you can also call Health Canada to get timely medical assistance.

Last but not least, intake of either form of doxycycline i.e., doxycycline hyclate or doxycycline monohydrate may cause discoloration of your baby teeth if you use during pregnancy. Often the infant’s teeth may become permanently become discolored. Hence, your caregiving team may never prescribe this antibiotic while you are pregnant. In order to obtain a complete list of precautions associated with the use of either doxycycline hyclate or doxycycline monohydrate, talk to your caregiver prior to starting your dosage plan.


Information provided here are only of supplementary nature. Information shared here does not substitute a qualified doctor’s advice. This website is not suggesting intake of this drug as safe or appropriate. Hence it is advised to talk to your doctor before consuming this med or any other drug.

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