How long does it take for Wellbutrin XL / SR to start working?

Antidepressants help boosts your feelings and moods. These drugs mostly work to restore the fine balance of transmitting substances present in your brain. Of the different types of antidepressants, the atypical genre is widely used. In this light, a drug called Wellbutrin (based on a generic med called Bupropion) is commonly administered to treat spells of depression. This drug is taken when first-line drugs such as selective serotonin reuptake inhibitors (SSRIs) fail to provide satisfactory responses. But, how long does it take for Wellbutrin XL / SR to start functioning? It is a wise thing to know more details.

Wellbutrin XL / SR – What is it?

These are different forms of antidepressants with capabilities to manage depression-related disorders such as MDD. It is also administered for treating seasonal affective disorders i.e., SAD. As an extended use, this med is taken for cessation of smoking tobacco-based products. The key active substances present in this med help restore the fine balance needed of transmitters present in your brain, and thus bring about a calming effect.

Wellbutrin is of the well-known norepinephrine/dopamine reuptake inhibitors (NDRIs). The drug influences the reabsorption of dopamine and norepinephrine and thus makes them available among the synapses. The same effects also help minimise carvings for tobacco-based products. Through an off-the-label use, this med is given to people with attention deficit hyperactivity disorder – ADHD, in short.

How long does it take for Wellbutrin XL / SR to act?

You may notice a marked change in your sleep cycles, appetite levels and energies within 10 days from the date of commencement of your treatment. However, it may take some time for the drug to start working on your moods as well as feelings. Based on prior evidences, it is known to take more than 5 weeks for the key chemicals of Wellbutrin to start functioning. Also, people who took this med may find their motivation levels to return to a normal after a few months.

XL and SR versions of Wellbutrin work almost in a similar manner. Both these formats inhibit cells of your central nervous system (CNS) from reabsorbing dopamine, norepinephrine form your brain layers. You need to know that these neurotransmitters help restore and regulate brain function, moods and feelings. As you pursue ahead with the treatment plan, your brain will find added level of transmitters and thus the odds of staying depressed are reduced to a considerable extent.

Most likely changes of taking either of these meds include – ability to remain focused, restoration of appetite level, ability to have a good sleep during night times, reduction or a complete stoppage of sad feelings or spells of hopelessness. As the names indicate, Wellbutrin XL stands for extended-release; owing to which, you are advised to take a single dose of it each day. On the other hand, Wellbutrin SR denotes sustained-release; this is prescribed two times within a 24-hour timeline.

In some people, these drugs may enhance the risks of suicides or harming oneself. Owing to such risks, it is highly recommended to closely watch the patient’s actions. In a few people, the active chemicals of Wellbutrin have caused convulsions, fits and/or seizures. This is one of the reasons for commencing the medication plan at fairly low dosage strengths. The way your body responds to the first few doses are closely monitored; upon sensing no major adverse reactions and side effects, the dosage strength is gradually increased.

Wellbutrin is sold in strengths ranging from 150 milligrams (mg) to 300 mg. However, Wellbutrin SR is available in strength of 200 mg as well. You may take these meds either before or after a meal. As none of these meds are to be taken as an over the counter (OTC) drug, it is essential to pursue your medication plan based on the guidance and supervision of a qualified medical specialist.

Jessica Martinez

Education: Doctor of Physical Therapy (DPT) from New York University. Experience: 5 years of experience writing for physiotherapy and sports medicine blogs, providing expert insights on injury prevention and rehabilitation.