Amlodipine Besylate Vs Amlodipine
Amlodipine BesylateAmlodipine
Calcium Channel BlockerDrug ClassCalcium Channel Blocker
Norvasc (most common brand)Brand NameAmlodipine (generic)
AmlodipineActive IngredientAmlodipine
Besylate SaltSalt FormDirect Amlodipine (no salt form)
Hypertension, Angina PectorisIndicationsHypertension, Angina Pectoris
Inhibits calcium ion influx into vascular smooth muscle and cardiac muscle, relaxing and dilating blood vesselsMechanism of ActionSame as Amlodipine Besylate
Once dailyDosing FrequencyOnce daily
Oral tablets, typically 2.5 mg, 5 mg, 10 mgFormulationOral tablets, typically 2.5 mg, 5 mg, 10 mg
30-50 hours (due to the besylate salt)Half-life30-50 hours
60-80% of the dose is absorbed orallyAbsorption60-80% of the dose is absorbed orally
Approximately 64-80%BioavailabilityApproximately 64-80%
Primarily metabolized in the liver by cytochrome P450 3A4MetabolismPrimarily metabolized in the liver by cytochrome P450 3A4
Mainly through the urineExcretionMainly through the urine
Common: Edema, dizziness, flushing, headache, fatigueSide EffectsSame as Amlodipine Besylate
Severe hypotension, shock, aortic stenosisContraindicationsSevere hypotension, shock, aortic stenosis
Can interact with other antihypertensive agents, cyclosporine, and othersDrug InteractionsCan interact with other antihypertensive agents, cyclosporine, and others
Category CPregnancy CategoryCategory C
Generally more expensive (due to brand)CostTypically cheaper (generic)
Yes, generic forms are available (Amlodipine Besylate)Generic AvailabilityYes, generic forms are available (Amlodipine)
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