Amoxicillin vs Augmentin
AmoxicillinAugmentin
Amoxicillin (a penicillin antibiotic)Active IngredientsAmoxicillin + Clavulanic Acid (a penicillin antibiotic with beta-lactamase inhibitor)
Antibiotic, PenicillinClassAntibiotic, Penicillin with beta-lactamase inhibitor
Inhibits bacterial cell wall synthesisMechanism of ActionInhibits bacterial cell wall synthesis; clavulanic acid protects amoxicillin from degradation by beta-lactamase enzymes
Mild to moderate bacterial infections: respiratory tract, urinary tract, skin infections, and ENT infectionsIndicationsSimilar infections as amoxicillin; also effective against beta-lactamase producing bacteria
Gram-positive and some Gram-negative bacteriaEffective AgainstGram-positive and beta-lactamase producing bacteria that amoxicillin alone cannot treat
Narrower spectrum than AugmentinSpectrum of ActivityBroader spectrum due to the addition of clavulanic acid
Oral capsules, tablets, chewable tablets, and suspensionDosage FormsOral tablets, chewable tablets, suspension, extended-release tablets
Varies: often 250-500 mg every 8 hours or 500-875 mg every 12 hoursCommon DosageVaries: often 500/125 mg every 8-12 hours or 875/125 mg every 12 hours
7-10 days, depending on infection type and severityTypical Duration7-14 days, depending on infection type and severity
Taken with or without foodAdministrationRecommended to take with food to reduce stomach upset
Nausea, diarrhea, rash, vomiting, allergic reactionsSide EffectsNausea, diarrhea (more frequent), rash, allergic reactions, abdominal pain
Limited in infections caused by beta-lactamase producing organismsEffectiveness in Resistant InfectionsEffective against beta-lactamase producing organisms
Category B (Generally considered safe during pregnancy)Pregnancy CategoryCategory B (Generally considered safe during pregnancy)
May interact with oral contraceptives, blood thinnersInteractionsMay interact with oral contraceptives, blood thinners, allopurinol
Generally cheaper than AugmentinCostMore expensive due to the combination of drugs
Store at room temperatureStorageStore at room temperature; suspension must be refrigerated
AvailableGeneric AvailabilityAvailable
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