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Doxycycline Hyclate vs Monohydrate

Doxycycline HyclateMonohydrate
Tetracycline antibiotic

Drug Class

Tetracycline antibiotic
Hyclate salt form (doxycycline hyclate)

Chemical Form

Monohydrate form (doxycycline monohydrate)
Inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit

Mechanism of Action

Inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit
1967 (for various infections)

FDA Approval Year

1967 (for various infections)
Respiratory infections, skin infections, UTIs, acne, Lyme disease, malaria prevention

Indications

Respiratory infections, skin infections, UTIs, acne, Lyme disease, malaria prevention
More soluble and potentially harsher on the stomach

Formulation Differences

Less soluble and generally milder on the stomach
100 mg, 200 mg tablets or capsules

Common Dosages

50 mg, 100 mg, 150 mg capsules
Absorbed well in acidic stomach environment

Absorption

Absorbed more consistently in varied pH levels
Can be taken with food but not dairy, which can reduce absorption

Food Interaction

Can be taken with food but not dairy, which can reduce absorption
Upset stomach, nausea, vomiting, diarrhea, photosensitivity, tooth discoloration in children

Side Effects

Similar side effects: upset stomach, nausea, vomiting, photosensitivity, tooth discoloration in children
Higher risk due to increased acidity

Risk of Esophageal Irritation

Lower risk, potentially gentler on the esophagus
Equally effective against susceptible infections

Effectiveness

Equally effective against susceptible infections
Generally less expensive

Cost

Typically more expensive due to formulation differences
Not recommended (Category D)

Pregnancy Category

Not recommended (Category D)
Caution in children under 8 and individuals with liver disease

Special Populations

Caution in children under 8 and individuals with liver disease
Store at room temperature, protect from light

Storage

Store at room temperature, protect from light
Widely available, generic options present

Availability

Widely available, generic options present
Hypersensitivity to doxycycline or other tetracyclines

Contraindications

Hypersensitivity to doxycycline or other tetracyclines

Coupon code

CMP30

Coupon code

Coupon code

CMP30