Doxycycline Hyclate vs Monohydrate
Doxycycline HyclateMonohydrate
Tetracycline antibiotic
Drug Class
Tetracycline antibioticHyclate salt form (doxycycline hyclate)
Chemical Form
Monohydrate form (doxycycline monohydrate)Inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit
Mechanism of Action
Inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit1967 (for various infections)
FDA Approval Year
1967 (for various infections)Respiratory infections, skin infections, UTIs, acne, Lyme disease, malaria prevention
Indications
Respiratory infections, skin infections, UTIs, acne, Lyme disease, malaria preventionMore soluble and potentially harsher on the stomach
Formulation Differences
Less soluble and generally milder on the stomach100 mg, 200 mg tablets or capsules
Common Dosages
50 mg, 100 mg, 150 mg capsulesAbsorbed well in acidic stomach environment
Absorption
Absorbed more consistently in varied pH levelsCan be taken with food but not dairy, which can reduce absorption
Food Interaction
Can be taken with food but not dairy, which can reduce absorptionUpset stomach, nausea, vomiting, diarrhea, photosensitivity, tooth discoloration in children
Side Effects
Similar side effects: upset stomach, nausea, vomiting, photosensitivity, tooth discoloration in childrenHigher risk due to increased acidity
Risk of Esophageal Irritation
Lower risk, potentially gentler on the esophagusEqually effective against susceptible infections
Effectiveness
Equally effective against susceptible infectionsGenerally less expensive
Cost
Typically more expensive due to formulation differencesNot recommended (Category D)
Pregnancy Category
Not recommended (Category D)Caution in children under 8 and individuals with liver disease
Special Populations
Caution in children under 8 and individuals with liver diseaseStore at room temperature, protect from light
Storage
Store at room temperature, protect from lightWidely available, generic options present
Availability
Widely available, generic options presentHypersensitivity to doxycycline or other tetracyclines
Contraindications
Hypersensitivity to doxycycline or other tetracyclinesGet Coupon Code
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