GABA VS Gabapentin
GABAGabapentin
NeurotransmitterClassificationAnticonvulsant and Nerve Pain Medication
Acts as an inhibitory neurotransmitter in the brain, reducing neuronal excitability.Mechanism of ActionModulates calcium channels, indirectly affecting GABA pathways. Does not directly interact with GABA receptors.
Anxiety relief - Sleep improvement - Stress reduction - Muscle relaxationUses- Neuropathic pain (e.g., diabetic neuropathy, postherpetic neuralgia) - Seizure disorders (partial seizures) - Restless legs syndrome - Off-label: Anxiety, migraines
Dietary supplements in pill, powder, or gummy formAdministrationPrescription medication in capsules, tablets, or oral solution
Typically 500–1,000 mg/day (varies based on supplement brand)DosageInitial: 300 mg/day; can be increased to 1,800–3,600 mg/day based on condition and patient response
Immediate to hours, depending on absorptionOnset of ActionTakes several days to weeks for full therapeutic effects
Short-lived (hours)Duration of Action5–7 hours for most effects, varies by formulation
Generally mild: - Drowsiness - Fatigue - Upset stomach (rare)Side EffectsCommon: - Drowsiness - Dizziness - Fatigue - Nausea - Peripheral edema Rare: - Mood changes - Suicidal thoughts - Allergic reactions
Rare, but not recommended for severe liver or kidney diseaseContraindications- Severe kidney disease (requires dose adjustment) - Allergy to gabapentin
Minimal; interacts with few medicationsDrug InteractionsAlcohol, opioids, and CNS depressants increase risk of sedation and dizziness
Over-the-counter (OTC) in most countriesAvailabilityPrescription only
Dietary supplement, not regulated as a drugLegal StatusControlled substance in some regions (e.g., UK); not scheduled in the US
Relatively inexpensive: $10–$30/monthCostModerate: $30–$100/month (depending on brand or generic)
Limited safety data; use with cautionPregnancy & LactationCategory C (US FDA): Use if benefits outweigh risks
Anecdotal; mixed evidence, may work as a mild relaxantEffectiveness for AnxietyOff-label use for anxiety, with stronger evidence compared to GABA
Limited clinical studies on supplementation effectivenessScientific EvidenceExtensive studies supporting its use for seizures and neuropathic pain
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