Horizant vs Gabapentin
Class
Anticonvulsant, neuropathic pain agentFDA Approved Uses
Postherpetic neuralgia - Epilepsy (adjunctive therapy) - Neuropathic pain associated with diabetic peripheral neuropathyFormulation
Capsules, tablets, oral solutionDosage Forms
100 mg, 300 mg, 400 mg, 600 mg, 800 mgMechanism of Action
Similar to Horizant; directly binds to the ?2? subunit of voltage-gated calcium channelsSide Effects
Dizziness - Somnolence - Headache - Fatigue - Nausea - InsomniaAdministration
Three times a day or as prescribedAbsorption/Bioavailability
Variable, 27-60% (decreases with increasing dose)Drug Interactions
Antacids containing aluminum or magnesium - Alcohol can increase the risk of CNS depression - Other CNS depressantsCost
Less expensive, available as genericSpecial Considerations
Dose needs adjustment in renal impairment - Withdrawal should be gradual to avoid adverse effectsCoupon code
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How much gabapentin is in Horizant?
Horizant contains gabapentin enacarbil, a prodrug of gabapentin. Each 600 mg tablet of Horizant, once metabolized, is equivalent to about 600 mg of gabapentin. This formulation allows for an extended-release, providing a controlled conversion to gabapentin in the body.
Can Horizant cause weight gain?
Weight gain is not commonly reported as a side effect of Horizant. However, like its counterpart gabapentin, individual responses can vary. If you're experiencing unusual weight changes while taking Horizant, consult your healthcare provider for personalized advice.
How does Horizant make you feel?
Horizant can help alleviate symptoms of RLS and nerve pain, making you feel more comfortable and less distressed by these conditions. However, it may cause side effects such as dizziness and drowsiness, which could affect your overall feeling of alertness and well-being.
Is gabapentin good for anxiety?
Gabapentin is often prescribed off-label for anxiety due to its calming effect on the nervous system. It is particularly noted for easing anxiety that accompanies other conditions like bipolar disorder or epilepsy. Consult with a healthcare professional to determine if it's suitable for your specific anxiety symptoms.
