Lisinopril vs Amlodipine
lisinoprilAmlodipine
Angiotensin-Converting Enzyme (ACE) InhibitorDrug ClassCalcium Channel Blocker (CCB)
Blocks ACE enzyme, reducing angiotensin II production, which relaxes blood vessels and lowers blood pressure.Mechanism of ActionInhibits calcium influx into vascular smooth muscle, causing relaxation of blood vessels and lowering blood pressure.
- High blood pressure (hypertension) - Heart failure - Reducing risk of stroke or heart attackUses- High blood pressure (hypertension) - Angina (chest pain) - Coronary artery disease
Tablets: 2.5 mg, 5 mg, 10 mg, 20 mgDosage FormsTablets: 2.5 mg, 5 mg, 10 mg
- Cough - Dizziness - Headache - FatigueCommon Side Effects- Swelling in legs or ankles (edema) - Dizziness - Flushing - Fatigue
- Angioedema (swelling of face, lips, throat) - High potassium levels (hyperkalemia)Serious Side Effects- Severe low blood pressure - Worsening of chest pain or heart attack (rare)
- Avoid in pregnancy - Monitor potassium levels - Use caution in kidney diseaseSpecial Precautions- Use caution in liver disease - May cause significant swelling in some individuals
- NSAIDs (reduce effectiveness) - Potassium supplements (increase potassium levels)Drug Interactions- Other blood pressure medications (enhance effects) - Grapefruit juice (may increase levels)
Category D (not safe for use during pregnancy)Pregnancy CategoryCategory C (use only if clearly needed)
No direct effect on heart rateEffect on Heart RateMay slightly lower heart rate
Can affect kidney function, especially in patients with kidney diseaseKidney Function ImpactLess impact on kidney function
12 hoursHalf-Life30-50 hours
Once dailyFrequency of DosingOnce daily
Not metabolized, excreted by the kidneysMetabolismMetabolized in the liver
Generally affordableCostGenerally affordable
Prinivil, ZestrilBrandsNorvasc
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