Lisinopril vs Metoprolol
LisinoprilMetoprolol
ACE inhibitorDrug ClassBeta-blocker
Hypertension, heart failure, post-myocardial infarctionIndicationsHypertension, angina, heart failure, post-MI, arrhythmias
Inhibits angiotensin-converting enzyme, reducing angiotensin II levels, decreasing blood pressure, and improving heart efficiencyMechanism of ActionBlocks beta-adrenergic receptors in the heart, reducing heart rate, cardiac output, and blood pressure
Oral tabletDosage FormsOral tablet, extended-release, intravenous
Cough, dizziness, headache, fatigue, hypotensionCommon Side EffectsDizziness, fatigue, depression, shortness of breath, bradycardia
Angioedema, hyperkalemia, renal impairment, hypotensionSerious Side EffectsHeart block, severe bradycardia, hypotension, heart failure exacerbation
History of angioedema related to previous ACE inhibitor therapy, pregnancyContraindicationsSevere bradycardia, heart block greater than first degree, severe heart failure, cardiogenic shock unless secondary to arrhythmia
NSAIDs, potassium supplements, diuretics, lithiumInteractionsAntidepressants, antipsychotics, other antihypertensives, CYP2D6 inhibitors
Blood pressure, renal function, potassium levelsMonitoringBlood pressure, heart rate, cardiac rhythm
Risk of angioedema, monitor kidney function especially in patients with renal insufficiencyNotable PrecautionsMay mask symptoms of hypoglycemia in diabetic patients, caution in asthma/COPD
D (US) - Positive evidence of riskPregnancy CategoryC (US) - Risk cannot be ruled out
Lower cost as it is commonly available as a genericCost (approx.)Generally low cost, both generic and brand available
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