Losartan vs Amlodipine
LosartanAmlodipine
Angiotensin II Receptor Blocker (ARB)Drug ClassCalcium Channel Blocker (CCB)
Blocks the action of angiotensin II, relaxing blood vessels and reducing blood pressure.Mechanism of ActionInhibits calcium influx in vascular smooth muscle and heart, causing vasodilation and lower blood pressure.
Hypertension - Diabetic nephropathy - Heart failure - Stroke preventionPrimary IndicationsHypertension - Angina (chronic stable, variant) - Coronary artery disease
Oral tablets 25 mg, 50 mg, 100 mgDosage FormsOral tablets (2.5 mg, 5 mg, 10 mg)
50–100 mg once dailyUsual Dosage5–10 mg once daily
Within 1–2 hoursOnset of Action6–12 hours
24 hoursDuration of Effect24–36 hours
2 hours (active metabolite: 6–9 hours)Half-Life30–50 hours
Liver (CYP2C9)MetabolismLiver (CYP3A4)
Urine (35%) and feces (60%)ExcretionUrine (10%) and feces (90%)
Dizziness - Fatigue - Nasal congestion - HyperkalemiaCommon Side EffectsSwelling (edema) - Dizziness - Flushing - Fatigue
Angioedema - Kidney dysfunctionSerious Side EffectsSevere hypotension - Heart palpitations - Rare: Liver dysfunction
Pregnancy - Severe kidney impairment - HypersensitivityContraindicationsSevere aortic stenosis - Hypersensitivity - Liver impairment
NSAIDs: Reduce efficacy - Potassium-sparing diuretics: Hyperkalemia riskDrug InteractionsGrapefruit: Increases drug levels - Beta-blockers: Enhanced hypotension
Caution in renal or hepatic impairmentUse in Special PopulationsCaution in severe hepatic impairment
Not recommended (Category D)Pregnancy CategoryNot recommended (Category C)
Limited data; use cautionBreastfeedingLikely safe; consult a doctor
Blood pressure - Renal function - Potassium levelsMonitoring ParametersBlood pressure - Signs of swelling (edema)
Renal protective effects - Reduces stroke risk - Low risk of coughBenefitsEffective for angina - Well-tolerated in most patients - No significant effects on kidney function
Hyperkalemia risk - May cause dizziness or fatigueDrawbacksCan cause peripheral edema - May require dose adjustments in liver disease
Generally affordable; available as a genericCostGenerally affordable; available as a generic
More suited for patients with kidney disease or diabetic nephropathyKey DifferencesBetter for angina and coronary artery disease patients
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