Lyrica vs Gabapentin
LyricaNeurontin, Gralise
Lyrica, Lyrica CRBrand namesNeurontin, Gralise
PregabalinGeneric NameGabapentin
Anticonvulsant, Neuropathic Pain AgentDrug classAnticonvulsant, Neuropathic Pain Agent
2004FDA Approval1993
Neuropathic pain (diabetes, shingles) - Fibromyalgia - Partial-onset seizures - Generalized anxiety disorder (GAD) - Spinal cord injury painuses- Neuropathic pain (diabetes, shingles) - Partial-onset seizures - Restless legs syndrome (RLS) - Postherpetic neuralgia
Modulates calcium channels to reduce excitatory neurotransmitter releaseMechanism of ActionModulates calcium channels to reduce excitatory neurotransmitter release
Capsules, oral solution, extended-release tabletsDosage FormsCapsules, oral solution, tablets
75 mg twice daily or 50 mg three times dailyInitial Dosage300 mg once daily, then increased to 300 mg three times daily
Up to 600 mg per dayMaximum DosageUp to 3600 mg per day
Approximately 6.3 hoursHalf-Life5 to 7 hours
Dizziness - Sleepiness - Weight gain - Dry mouth - Blurred vision - Swelling (edema)Common Side Effects- Dizziness - Sleepiness - Fatigue - Weight gain - Peripheral edema - Difficulty concentrating
Allergic reactions - AngioedemaSerious Side Effects- Severe allergic reactions - Respiratory depression
Category C (Risk cannot be ruled out)Pregnancy CategoryCategory C (Risk cannot be ruled out)
Schedule V (potential for abuse is low)Controlled SubstanceNot a controlled substance
Generally higher due to patent protectionCostGenerally lower as it\'s available as a generic
Approximately 1 hourOnset of Action1 to 2 hours
- CNS depressants - ACE inhibitors - Antidiabetic medicationsDrug Interactions- CNS depressants - Antacids (may reduce absorption) - Opioids
Dosage adjustment required for kidney impairmentRenal AdjustmentDosage adjustment required for kidney impairment
- Insomnia - Headache - Nausea - AnxietyWithdrawal SymptomsAgitation - Anxiety - Sweating - Insomnia
~90% (Not significantly dose-dependent)Bioavailability~27-60% (Decreases with higher doses)
Up to 12 hoursDuration of ActionUp to 8 hours
Not significantly metabolizedMetabolismNot significantly metabolized
Renal (over 90% unchanged)ExcretionRenal (unchanged)
- Faster onset - May be more effective for certain neuropathic pain conditionsAdvantage Over Each Other- Less expensive - More dosing flexibility
Taper off gradually to avoid withdrawal symptomsDiscontinuationTaper off gradually to avoid withdrawal symptoms
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