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Medrol Dose Pack vs Prednisone

Medrol Dose PackPrednisone
CorticosteroidDrug ClassCorticosteroid
Oral tabletsFormulationOral tablets, Liquid, Concentrated solution
Typically 4 mg tablets in a dose packDosage FormsVaries (1 mg, 2.5 mg, 5 mg, 10 mg, 20 mg, 50 mg tablets)
Allergic reactions, asthma, arthritis, inflammatory conditionsCommon UsesInflammatory conditions, asthma, autoimmune disorders, severe allergies, and chronic obstructive pulmonary disease
6-day tapering dose pack starting higher and decreasing graduallyAdministration ScheduleDose varies; often started at a higher dose then tapered based on condition and response
Insomnia, nausea, sweating, headache, dizziness, mood swings, increased blood sugar levels, possible weight gainSide EffectsIncreased appetite, weight gain, disturbances in electrolyte levels, increased blood sugar, mood swings, insomnia, potential long-term bone loss
Short to medium acting (12-36 hours)Duration of ActionIntermediate acting (18-36 hours)
Slightly more potent on a per mg basis compared to prednisonePotencySlightly less potent per mg compared to methylprednisolone
80-90%BioavailabilityApproximately 70%
18 to 36 hoursHalf-Life1 to 3 hours (but the biological half-life is 18 to 36 hours)
Can interact with anticoagulants, diabetes medication, vaccines, and certain antibioticsInteractionSimilar interactions as methylprednisolone, plus potentially enhanced effects of anticoagulants
Category C (Risk not ruled out)Pregnancy CategoryCategory C (Risk not ruled out)
Dose pack designed for short-term use to reduce potential for side effectsSpecial ConsiderationsLong-term use requires monitoring for bone density, adrenal suppression, and other potential long-term effects

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