Melatonin vs Trazodone
MelatoninTrazodone
Natural hormone/supplementDrug TypePrescription medication (antidepressant, used off-label for sleep)
Dietary supplementDrug ClassSerotonin antagonist and reuptake inhibitor (SARI)
Mimics the body’s natural melatonin to regulate sleep-wake cyclesMechanism of ActionIncreases serotonin levels and blocks histamine, promoting sedation
Sleep disorders, jet lag, sleep-wake cycle regulationPrimary UseDepression, off-label for insomnia
Effective for mild sleep issues and short-term useEffectiveness for SleepMore effective for moderate to severe insomnia
Tablets, gummies, liquid, capsules, patchesDosage FormsTablets
1-10 mg, typically 30-60 minutes before bedtimeCommon Dosages25-100 mg, 30 minutes to 1 hour before bedtime
Short half-life; effects last 4-8 hours depending on formulationTypical Duration of ActionLonger duration; effects last around 6-8 hours
Within 30 minutes to 1 hourOnset of Action30 minutes to 1 hour
Taken at the same time each evening for best resultsAdministrationTaken at bedtime
Drowsiness, dizziness, headache, nauseaSide EffectsDrowsiness, dizziness, dry mouth, constipation, blurred vision
Low; generally considered safe for short-term useRisk of DependencyLow to moderate; not recommended for long-term use without monitoring
Can interact with sedatives, anticoagulants, immunosuppressantsInteractionsMay interact with alcohol, other sedatives, certain antidepressants
Not well-studied; generally recommended only if necessaryPregnancy CategoryCategory C (risk cannot be ruled out)
Available over-the-counterPrescription RequirementPrescription only
Widely available in drugstores and online as a supplementAvailabilityRequires a doctor’s prescription
Effective for adjusting sleep patternsEffectiveness for Jet LagNot typically used for jet lag
Not used for depressionUse in DepressionPrimarily prescribed for depression but used off-label for sleep
Sometimes used, but under doctor supervisionUsage in ChildrenGenerally not recommended for children for sleep
Room temperatureStorageRoom temperature, away from moisture
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