Methylprednisolone vs Prednisone
MethylprednisolonePrednisone
CorticosteroidDrug ClassCorticosteroid
18-36 hoursHalf-Life2-4 hours (but converted to active form prednisolone in the liver)
Typically faster (1-2 hours)Onset of ActionSlightly slower (2-4 hours)
Similar to prednisone but may cause less water retentionCommon Side EffectsSimilar to methylprednisolone but may cause more water retention and weight gain
Category C (Risk cannot be ruled out)Pregnancy CategoryCategory D (Evidence of risk, but benefits may outweigh risks in some situations)
Longer duration, often preferred for reducing inflammation quicklyDuration of ActionShorter duration, more frequent dosing may be needed
More potent (4 mg of methylprednisolone = 5 mg of prednisone)potencyLess potent compared to methylprednisolone
Oral tablets, injectionForms availableOral tablets
Often used for severe allergic reactions, asthma, and autoimmune diseasesUse in Specific ConditionsCommonly used for chronic conditions like asthma, rheumatoid arthritis, and allergies
4 mg methylprednisolone = 5 mg prednisoneConversion5 mg prednisone = 4 mg methylprednisolone
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