Metoprolol Tartrate vs Metoprolol Succinate

LopressorBrand namesToprol-XL

Taken 2-4 times per dayDosage FormsTaken once daily

Approximately 50%BioavailabilitySimilar bioavailability (~50%)

Faster onsetOnset of ActionSlower onset due to extended-release nature

Fatigue, dizziness, bradycardia, hypotensionCommon Side EffectsSimilar side effects, but may vary based on dosing schedule

CPregnancy CategoryC

Generally less expensiveCostMay be more expensive than tartrate

Not typically used for heart failureHart failure treatmentApproved for treating heart failure

Must be taken with or immediately after mealsAdministrationCan be taken without regard to meals

50 mg - 100 mg per doseCommon doses25 mg - 200 mg per dose

Immediate-releaseTypeExtended-release

Shorter duration, requires multiple dosesDuration of ActionLonger duration, sustained effect

Liver (CYP2D6 enzyme)MetabolismLiver (CYP2D6 enzyme)

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