Pregabalin vs Gabapentin
PregabalinGabapentin
LyricaBrand namesNeurontin
Anticonvulsant, Neuropathic Pain AgentDrug ClassAnticonvulsant, Neuropathic Pain Agent
Nerve pain (neuropathy), Fibromyalgia, Seizures (partial onset), Generalized anxiety disorder (GAD)UsesNerve pain (neuropathy), Seizures (partial onset), Postherpetic neuralgia
Modulates calcium channels to reduce neurotransmitter releaseMechanism of ActionModulates calcium channels to reduce neurotransmitter release
Capsules, Oral SolutionDosage FormsCapsules, Tablets, Oral Solution
75 mg twice dailyStarting Dose300 mg once daily
600 mg per dayMaximum Dose3600 mg per day
6.3 hoursHalf-Life5 to 7 hours
High and consistent (>90%)BioavailabilityDecreases with higher doses (60-70%)
Faster onset (within a few days)Onset of ActionSlower onset (may take weeks)
Dizziness, sleepiness, dry mouth, weight gainCommon Side EffectsDizziness, sleepiness, fatigue, ataxia
C (Risk cannot be ruled out)Pregnancy CategoryC (Risk cannot be ruled out)
Schedule V (low potential for abuse)Controlled SubstanceNot a controlled substance
Typically higherCostTypically lower
Yes, requires taperingWithdrawal SymptomsYes, requires tapering
2004FDA Approval1993
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