Ranitidine vs Famotidine
RanitidineFamotidine
H2 Receptor AntagonistDrug ClassH2 Receptor Antagonist
GERD, peptic ulcers, Zollinger-Ellison syndrome, heartburn.IndicationsGERD, peptic ulcers, Zollinger-Ellison syndrome, heartburn.
Blocks histamine H2 receptors in stomach lining to reduce acid production.Mechanism of ActionBlocks histamine H2 receptors in stomach lining to reduce acid production.
Oral (tablet, syrup, effervescent); intravenous (IV)Administration RouteOral (tablet, chewable tablet, suspension); intravenous (IV)
Typically 150 mg twice daily or 300 mg once daily.DosageTypically 20 mg twice daily or 40 mg once daily.
Headache, constipation, diarrhea, abdominal pain.Common Side EffectsHeadache, constipation, diarrhea, dizziness.
Rare: arrhythmias, liver enzyme changes, blood disorders.Severe Side EffectsRare: arrhythmias, seizures, liver enzyme changes.
May interfere with drugs requiring acidic pH for absorption (e.g., ketoconazole).Drug InteractionsSimilar to Ranitidine; slightly fewer drug interactions.
2–3 hoursHalf-Life2.5–3.5 hours
Partially metabolized in the liver; excreted primarily in urine.MetabolismMinimal liver metabolism; mostly excreted unchanged in urine.
Urine (mainly as metabolites)ExcretionUrine (majority unchanged)
Category B (safe in pregnancy; consult a doctor)Pregnancy CategoryCategory B (safe in pregnancy; consult a doctor)
Excreted in breast milk; use with caution.LactationExcreted in breast milk; use with caution.
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