Semaglutide vs Wegovy
SemaglutideWegovy
SemaglutideGeneric NameSemaglutide
Ozempic, RybelsusBrand NamesWegovy
Type 2 diabetes (Ozempic, Rybelsus); Chronic weight management (Wegovy)FDA Approved UseChronic weight management
GLP-1 receptor agonist that increases insulin secretion, reduces glucagon secretion, and slows gastric emptyingMechanism of ActionSame as Semaglutide (GLP-1 receptor agonist)
Ozempic: Injectable; Rybelsus: OralDosage FormsInjectable
Ozempic: 0.5 mg to 1 mg weekly; Rybelsus: 7 mg to 14 mg dailyDosageStart at 0.25 mg weekly, up to 2.4 mg weekly
Nausea, vomiting, diarrhea, abdominal pain, reduced appetiteCommon Side EffectsNausea, diarrhea, vomiting, constipation, abdominal pain
Generally lower compared to Wegovy but varies based on insuranceCostTypically higher, varies with insurance coverage
Effective in lowering blood glucose and A1C levels; also aids in weight lossEfficacyPrimarily used for weight loss, significant reduction in body weight
Not for treating type 1 diabetes or diabetic ketoacidosis. Can be used off-label for weight loss (Ozempic)ConsiderationsNot for treating type 1 diabetes or diabetic ketoacidosis. Designed specifically for weight loss
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