Sertraline vs Lexapro

Selective Serotonin Reuptake Inhibitor (SSRI)Drug ClassSelective Serotonin Reuptake Inhibitor (SSRI)

Depression, anxiety disorders, OCD, PTSD, panic disorderPrimary UseDepression, generalized anxiety disorder (GAD)

Tablets, oral concentrateDosage FormsTablets, oral solution

Nausea, diarrhea, insomnia, dry mouth, fatigue, sweatingCommon Side EffectsNausea, fatigue, insomnia, dizziness, sexual dysfunction

~26 hours (active metabolite: 62–104 hours)Half-life~27–32 hours

May interact with MAOIs, NSAIDs, anticoagulants, triptansDrug InteractionsMay interact with MAOIs, NSAIDs, anticoagulants, CYP2C19 inhibitors

Category C (risk not ruled out)Pregnancy CategoryCategory C (risk not ruled out)

Low levels found in breast milk; generally considered safeBreastfeedingLow levels found in breast milk; generally considered safe

Anxiety, irritability, dizziness, nausea, insomniaWithdrawal SymptomsAnxiety, irritability, dizziness, nausea, insomnia

Typically lowerCostGenerally affordable, slightly higher than Sertraline

Similar efficacy for depression and anxietyEffectivenessSimilar efficacy for depression and anxiety

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