Tirzepatide vs Semaglutide
TirzepatideSemaglutide
Dual GIP and GLP-1 receptor agonistDrug ClassGLP-1 receptor agonist
Activates both GLP-1 and GIP receptors, enhancing insulin secretion, reducing glucagon, slowing gastric emptyingMechanism of ActionActivates GLP-1 receptor, increasing insulin secretion, reducing glucagon, and slowing gastric emptying
2022FDA Approval Year2017 (for type 2 diabetes), 2021 (for weight management)
Type 2 Diabetes, weight management (under review)IndicationsType 2 Diabetes, weight management (Wegovy brand)
MounjaroBrand NamesOzempic (Type 2 diabetes), Wegovy (weight management)
Subcutaneous injectionDosage FormsSubcutaneous injection
Once weeklyDosing FrequencyOnce weekly
5 mg, 10 mg, 15 mgCommon Dosages0.5 mg, 1 mg, 2 mg (Ozempic); up to 2.4 mg (Wegovy)
Reduces A1C by ~2% to 2.4%Effect on A1CReduces A1C by ~1% to 1.8%
~12-22% of body weightWeight Loss Potential~10-15% of body weight
Nausea, diarrhea, decreased appetite, constipation, vomiting, fatigueNotable Side EffectsNausea, vomiting, diarrhea, abdominal pain, constipation
Low risk, but increases with concurrent sulfonylurea or insulinRisk of HypoglycemiaLow risk, but increases with concurrent sulfonylurea or insulin
Cardiovascular benefits seen, but more studies are ongoingCardiovascular BenefitsCardiovascular benefits, especially in those with established heart disease
History of medullary thyroid carcinoma (MTC), Multiple Endocrine Neoplasia syndrome type 2 (MEN2), hypersensitivity to the drugContraindicationsHistory of MTC, MEN2, hypersensitivity to the drug
Not recommended in severe renal impairment, use cautiously in liver impairmentSpecial PopulationsUse with caution in renal impairment, consult with healthcare provider in severe renal or liver impairment
Not recommended during pregnancyPregnancy CategoryNot recommended during pregnancy
High (around $1000+ per month)Average CostHigh (around $800+ per month for Ozempic; Wegovy prices may vary)
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