Tizanidine vs Flexeril
TizanidineFlexeril
Centrally acting muscle relaxantDrug ClassCentrally acting muscle relaxant
Alpha-2 adrenergic agonist that reduces nerve impulses to relax muscles.Mechanism of ActionReduces motor neuron activity in the brainstem, decreasing muscle spasm.
Muscle spasticity associated with conditions like multiple sclerosis and spinal cord injury.Common UsesMuscle spasms from acute musculoskeletal conditions (e.g., back pain).
1–2 hoursOnset of Action1 hour
4–6 hoursDuration of Action12–24 hours
Tablets, CapsulesDosage FormTablets
2 mg, increased based on tolerance (max: 36 mg/day)Typical Starting Dose5–10 mg up to 3 times daily (max: 30 mg/day)
Drowsiness, Dry mouthCommon Side EffectsDrowsiness , Dry mouth
Low blood pressure (hypotension)Serious Side EffectsSerotonin syndrome (rare, when combined with other drugs)
CNS depressants (e.g., alcohol, benzodiazepines)Drug InteractionsCNS depressants
Avoid abrupt discontinuation (risk of rebound hypertension).WarningsUse cautiously in patients with heart conditions.
Not recommended (insufficient data)Pregnancy CategoryCategory B: Safe but should be used only if necessary
Generally low for genericCostGenerally low for generic
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