Trazodone VS Xanax
TrazodoneXanax
Serotonin antagonist and reuptake inhibitor (SARI)Drug ClassBenzodiazepine
Treatment of depression and insomniaPrimary UseTreatment of anxiety disorders and panic disorders
Inhibits serotonin reuptake and blocks certain serotonin receptors, leading to improved mood and sedation.Mechanism of ActionEnhances the activity of GABA, a calming neurotransmitter, resulting in anxiolytic and sedative effects.
1–2 weeks for antidepressant effects; 30–60 minutes for sedationOnset of Action15–30 minutes for anxiety relief
6–9 hoursDuration of Action6–12 hours
7–13 hoursHalf-Life11–16 hours
DepressionFDA-Approved IndicationsAnxiety disorders, panic disorder
Insomnia, anxiety, chronic pain, alcohol withdrawalOff-Label UsesInsomnia, agitation, depression (adjunct)
Drowsiness, dizziness, dry mouth, constipation, blurred vision, priapism (rare)Side EffectsDrowsiness, dizziness, dependence, fatigue, memory issues, respiratory depression (rare)
LowRisk of DependenceHigh
Category CPregnancy CategoryCategory D
NoControlled SubstanceYes (Schedule IV)
Mild: Insomnia, anxietyWithdrawal SymptomsSevere: Anxiety, insomnia, seizures, irritability
Sedation, cardiac arrhythmias, seizures (rarely fatal)Overdose RiskRespiratory depression, coma, death (in high doses)
MAOIs, SSRIs, alcohol, sedativesDrug InteractionsAlcohol, opioids, other CNS depressants
25–300 mg daily, depending on conditionDosage Range0.25–4 mg daily, divided doses
Orally, typically at bedtimeHow It’s TakenOrally, 2–3 times daily as prescribed
Can be used long-term under supervisionLong-Term UseNot recommended due to risk of dependence
Generally lowCost (Generic)Low to moderate
Effective for depression and insomnia; slower onsetEffectivenessHighly effective for acute anxiety and panic attacks
Taper dosage gradually to avoid withdrawal symptoms.Special ConsiderationsAvoid abrupt discontinuation due to withdrawal risk.
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