Amlodipine vs Metoprolol
Drug Class
Beta-1 Selective Beta-BlockerPrimary Indications
- Hypertension - Angina (chest pain) - Heart failure (Metoprolol succinate) - Post-heart attack preventionMechanism of Action
Blocks beta-1 receptors, slowing heart rate and reducing blood pressure.Dosage Forms
Oral tablets, extended-release tablets, IV injectionCommon Dosages
- Hypertension: 25–100 mg twice daily (IR), 25–200 mg once daily (ER) - Heart failure: 12.5–200 mg daily (ER)Onset of Action
1 hour (IR), 4–6 hours (ER)Duration of Action
IR: 6–12 hours ER: 24 hoursHalf-Life
IR: 3–7 hours ER: 7–9 hoursCommon Side Effects
- Fatigue - Dizziness - Slow heart rate - Cold hands/feetSerious Side Effects
- Bradycardia (slow heart rate) - Low blood pressure - Depression - Worsening heart failurePregnancy Category
Category C (Use with caution)Controlled Substance
NoAddiction Potential
NoneDrug Interactions
- Other beta-blockers - Calcium channel blockers - Digoxin (bradycardia risk)Monitoring Parameters
- Blood pressure - Heart rate - Symptoms of heart failureWithdrawal Symptoms
- Rebound hypertension - Chest pain - Increased heart rateCost and Availability
Affordable, available as genericSpecial Considerations
- More effective for heart-related conditions (e.g., heart failure, post-heart attack). - Slows heart rate, which may be beneficial for some conditions.Coupon code
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What is the main difference between Amlodipine and Metoprolol?
Amlodipine is a calcium channel blocker that relaxes blood vessels, reducing blood pressure without slowing the heart rate. Metoprolol is a beta-blocker that lowers both blood pressure and heart rate, making it better for heart conditions.
Which medication is better for high blood pressure?
Both are effective, but Amlodipine is often preferred for hypertension, especially in African American patients. Metoprolol is better suited for patients with heart failure or a history of heart attacks.
Can Amlodipine and Metoprolol be taken together?
Yes, doctors sometimes prescribe them together because they work differently—Amlodipine lowers blood pressure by relaxing blood vessels, while Metoprolol reduces heart rate and cardiac workload.
What are the most common side effects of Amlodipine and Metoprolol?
Amlodipine may cause swelling (edema), dizziness, and flushing, while Metoprolol can lead to fatigue, slow heart rate, and cold extremities. Always consult your doctor if side effects persist.
