Bisoprolol vs Metoprolol
BisoprololMetoprolol
Beta-1 selective beta-blockerDrug ClassBeta-1 selective beta-blocker
- Hypertension - Chronic heart failure - Stable anginaIndications- Hypertension - Chronic heart failure - Angina - Myocardial infarction prevention - Atrial fibrillation
Blocks beta-1 adrenergic receptors, reducing heart rate and cardiac workload.Mechanism of ActionBlocks beta-1 adrenergic receptors, reducing heart rate, cardiac output, and oxygen demand.
Oral tablets (e.g., 5 mg, 10 mg)Dosage FormsOral tablets (e.g., 25 mg, 50 mg, 100 mg); Extended-release tablets (e.g., 25 mg, 50 mg, 100 mg, 200 mg)
Once dailyDosing FrequencyImmediate-release: 2–3 times daily Extended-release: Once daily
~80%Bioavailability~50% (immediate-release); ~60–70% (extended-release)
~9–12 hoursHalf-life~3–7 hours (immediate-release); ~5–7 hours (extended-release)
Liver metabolism via CYP3A4MetabolismLiver metabolism via CYP2D6
Renal and fecal (50% unchanged in urine)ExcretionRenal and fecal (mostly as metabolites)
Requires dose adjustment in renal impairment.Special PopulationsCaution in severe hepatic impairment.
- Fatigue - Bradycardia - Dizziness - Cold extremities - NauseaCommon Side Effects- Fatigue - Bradycardia - Dizziness - Hypotension - Depression
- Severe bradycardia - Heart block - BronchospasmSerious Side Effects- Severe bradycardia - Heart block - Worsening heart failure - Bronchospasm
Category C (Risk cannot be ruled out)Pregnancy CategoryCategory C (Risk cannot be ruled out)
Use with caution; limited data available.LactationUse with caution; excreted in breast milk.
- Calcium channel blockers (e.g., Verapamil, Diltiazem) - Digoxin - Insulin - NSAIDs - CYP3A4 inhibitorsDrug Interactions- Calcium channel blockers - Digoxin - Insulin - NSAIDs - CYP2D6 inhibitors
Strongly decreases heart rateEffect on Heart RateDecreases heart rate (may vary between forms)
Often preferred for chronic heart failure due to longer half-life and once-daily dosing.Preferred UsageOften used post-MI or in atrial fibrillation due to immediate-release forms and higher flexibility.
Zebeta (common brand)Brand NamesLopressor (immediate-release), Toprol-XL (extended-release)
Generally affordableCost (Generic)Generally affordable, extended-release forms may cost more.
Longer half-life and steady effect make it suitable for once-daily dosing.Key DifferencesMore flexibility in dosing frequency; extended-release offers smoother effect.
Get Coupon Code
Enter your email Get your coupon code for more discount
Get Coupon Code
Enter your email Get your coupon code for more discount
Exclusive 30% OFF for New Customers!
