Cefdinir vs Amoxicillin
CefdinirAmoxicillin
Cephalosporin Antibiotic (3rd Generation)
Drug Class
Penicillin AntibioticOmnicef, Others
Brand Names
Amoxil, Moxatag, OthersInhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)
Mechanism of Action
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)Respiratory tract infections (e.g., bronchitis, sinusitis), Skin infections, Otitis media
Indications
Respiratory tract infections, Otitis media, Skin infections, Urinary tract infections, Dental infectionsBroad-spectrum against Gram-positive and some Gram-negative bacteria
Spectrum of Activity
Broad-spectrum with more coverage for Gram-positive bacteriaCapsules, Oral Suspension
Dosage Forms
Capsules, Tablets, Chewable Tablets, Oral SuspensionAdults: 300 mg twice daily or 600 mg once daily; Children: 14 mg/kg once daily or divided doses
Typical Dosage
Adults: 500 mg every 8 hours or 875 mg every 12 hours; Children: 20–40 mg/kg/day in divided dosesWithin 1–2 hours
Onset of Action
Within 1–2 hours5–10 days depending on infection
Duration of Therapy
5–10 days depending on infectionMinimal hepatic metabolism
Metabolism
Minimal hepatic metabolismCategory B (safe in pregnancy)
Pregnancy Category
Category B (safe in pregnancy)Diarrhea, Nausea, Rash, Vaginal yeast infections, Headache
Side Effects
Nausea, Vomiting, Diarrhea, Rash, Allergic reactionsGenerally safe for patients with mild penicillin allergy
Use in Penicillin Allergy
Not safe for patients with penicillin allergyEffective for infections caused by resistant bacteria; can cause reddish stool when taken with iron
Special Considerations
Effective and widely used; available in combination with clavulanate for resistant infectionsAntacids, Iron supplements (reduce absorption)
Interactions
Oral contraceptives (reduced effectiveness), Allopurinol (increased rash risk)Severe hypersensitivity to cephalosporins
Contraindications
Hypersensitivity to penicillinsGet Coupon Code
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