Cefdinir vs Amoxicillin
CefdinirAmoxicillin
Cephalosporin Antibiotic (3rd Generation)Drug ClassPenicillin Antibiotic
Omnicef, OthersBrand NamesAmoxil, Moxatag, Others
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)Mechanism of ActionInhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)
Respiratory tract infections (e.g., bronchitis, sinusitis), Skin infections, Otitis mediaIndicationsRespiratory tract infections, Otitis media, Skin infections, Urinary tract infections, Dental infections
Broad-spectrum against Gram-positive and some Gram-negative bacteriaSpectrum of ActivityBroad-spectrum with more coverage for Gram-positive bacteria
Capsules, Oral SuspensionDosage FormsCapsules, Tablets, Chewable Tablets, Oral Suspension
Adults: 300 mg twice daily or 600 mg once daily; Children: 14 mg/kg once daily or divided dosesTypical DosageAdults: 500 mg every 8 hours or 875 mg every 12 hours; Children: 20–40 mg/kg/day in divided doses
Within 1–2 hoursOnset of ActionWithin 1–2 hours
5–10 days depending on infectionDuration of Therapy5–10 days depending on infection
Minimal hepatic metabolismMetabolismMinimal hepatic metabolism
Category B (safe in pregnancy)Pregnancy CategoryCategory B (safe in pregnancy)
Diarrhea, Nausea, Rash, Vaginal yeast infections, HeadacheSide EffectsNausea, Vomiting, Diarrhea, Rash, Allergic reactions
Generally safe for patients with mild penicillin allergyUse in Penicillin AllergyNot safe for patients with penicillin allergy
Effective for infections caused by resistant bacteria; can cause reddish stool when taken with ironSpecial ConsiderationsEffective and widely used; available in combination with clavulanate for resistant infections
Antacids, Iron supplements (reduce absorption)InteractionsOral contraceptives (reduced effectiveness), Allopurinol (increased rash risk)
Severe hypersensitivity to cephalosporinsContraindicationsHypersensitivity to penicillins
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