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Cefdinir vs Amoxicillin

CefdinirAmoxicillin
Cephalosporin Antibiotic (3rd Generation)

Drug Class

Penicillin Antibiotic
Omnicef, Others

Brand Names

Amoxil, Moxatag, Others
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)

Mechanism of Action

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)
Respiratory tract infections (e.g., bronchitis, sinusitis), Skin infections, Otitis media

Indications

Respiratory tract infections, Otitis media, Skin infections, Urinary tract infections, Dental infections
Broad-spectrum against Gram-positive and some Gram-negative bacteria

Spectrum of Activity

Broad-spectrum with more coverage for Gram-positive bacteria
Capsules, Oral Suspension

Dosage Forms

Capsules, Tablets, Chewable Tablets, Oral Suspension
Adults: 300 mg twice daily or 600 mg once daily; Children: 14 mg/kg once daily or divided doses

Typical Dosage

Adults: 500 mg every 8 hours or 875 mg every 12 hours; Children: 20–40 mg/kg/day in divided doses
Within 1–2 hours

Onset of Action

Within 1–2 hours
5–10 days depending on infection

Duration of Therapy

5–10 days depending on infection
Minimal hepatic metabolism

Metabolism

Minimal hepatic metabolism
Category B (safe in pregnancy)

Pregnancy Category

Category B (safe in pregnancy)
Diarrhea, Nausea, Rash, Vaginal yeast infections, Headache

Side Effects

Nausea, Vomiting, Diarrhea, Rash, Allergic reactions
Generally safe for patients with mild penicillin allergy

Use in Penicillin Allergy

Not safe for patients with penicillin allergy
Effective for infections caused by resistant bacteria; can cause reddish stool when taken with iron

Special Considerations

Effective and widely used; available in combination with clavulanate for resistant infections
Antacids, Iron supplements (reduce absorption)

Interactions

Oral contraceptives (reduced effectiveness), Allopurinol (increased rash risk)
Severe hypersensitivity to cephalosporins

Contraindications

Hypersensitivity to penicillins

Coupon code

CMP30

Coupon code

Coupon code

CMP30