Coreg vs Metoprolol
Drug Class
Beta-1 Selective Beta-BlockerPrimary Indications
- Hypertension - Angina (chest pain) - Heart failure (Metoprolol succinate) - Post-heart attack preventionMechanism of Action
Blocks beta-1 receptors, slowing heart rate and reducing blood pressure.Dosage Forms
Oral tablets, extended-release tablets, IV injectionCommon Dosages
- Hypertension: 25–100 mg twice daily (IR), 25–200 mg once daily (ER) - Heart failure: 12.5–200 mg daily (ER)Onset of Action
1 hour (IR), 4–6 hours (ER)Duration of Action
IR: 6–12 hours ER: 24 hoursHalf-Life
IR: 3–7 hours ER: 7–9 hoursCommon Side Effects
- Fatigue - Dizziness - Slow heart rate - Cold hands/feetSerious Side Effects
- Bradycardia - Low blood pressure - Shortness of breath - DepressionPregnancy Category
Category C (Use with caution)Controlled Substance
NoAddiction Potential
NoneDrug Interactions
- Other beta-blockers - Calcium channel blockers - Digoxin (bradycardia risk)Monitoring Parameters
- Blood pressure - Heart rate - Symptoms of heart failureWithdrawal Symptoms
- Rebound hypertension - Chest pain - Increased heart rateCost and Availability
Generic available, affordableSpecial Considerations
- More cardio-selective (targets only beta-1 receptors). - Better tolerated in asthma/COPD patients.Coupon code
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What is the main difference between Coreg and Metoprolol?
Coreg (Carvedilol) blocks both beta and alpha receptors, reducing heart rate and relaxing blood vessels. Metoprolol is beta-1 selective, mainly slowing heart rate and lowering blood pressure without affecting blood vessel dilation.
Which medication is better for heart failure?
Both are used for heart failure, but Coreg is preferred for heart failure with reduced ejection fraction (HFrEF) because it also relaxes blood vessels. Metoprolol succinate (Toprol XL) is another effective option, especially for post-heart attack care.
Can Coreg or Metoprolol be taken by asthma or COPD patients?
Metoprolol is usually preferred in patients with asthma or COPD because it selectively targets beta-1 receptors. Coreg blocks beta-2 receptors, which can cause bronchoconstriction, making it riskier for respiratory conditions.
Which medication has fewer side effects?
Both can cause fatigue, dizziness, and low blood pressure, but Coreg may cause more dizziness and fatigue due to its alpha-blocking effect. Metoprolol may cause more cold hands/feet and slow heart rate.
