Doxycycline Hyclate vs Monohydrate
Doxycycline HyclateMonohydrate
Tetracycline antibioticDrug ClassTetracycline antibiotic
Hyclate salt form (doxycycline hyclate)Chemical FormMonohydrate form (doxycycline monohydrate)
Inhibits bacterial protein synthesis by binding to the 30S ribosomal subunitMechanism of ActionInhibits bacterial protein synthesis by binding to the 30S ribosomal subunit
1967 (for various infections)FDA Approval Year1967 (for various infections)
Respiratory infections, skin infections, UTIs, acne, Lyme disease, malaria preventionIndicationsRespiratory infections, skin infections, UTIs, acne, Lyme disease, malaria prevention
More soluble and potentially harsher on the stomachFormulation DifferencesLess soluble and generally milder on the stomach
100 mg, 200 mg tablets or capsulesCommon Dosages50 mg, 100 mg, 150 mg capsules
Absorbed well in acidic stomach environmentAbsorptionAbsorbed more consistently in varied pH levels
Can be taken with food but not dairy, which can reduce absorptionFood InteractionCan be taken with food but not dairy, which can reduce absorption
Upset stomach, nausea, vomiting, diarrhea, photosensitivity, tooth discoloration in childrenSide EffectsSimilar side effects: upset stomach, nausea, vomiting, photosensitivity, tooth discoloration in children
Higher risk due to increased acidityRisk of Esophageal IrritationLower risk, potentially gentler on the esophagus
Equally effective against susceptible infectionsEffectivenessEqually effective against susceptible infections
Generally less expensiveCostTypically more expensive due to formulation differences
Not recommended (Category D)Pregnancy CategoryNot recommended (Category D)
Caution in children under 8 and individuals with liver diseaseSpecial PopulationsCaution in children under 8 and individuals with liver disease
Store at room temperature, protect from lightStorageStore at room temperature, protect from light
Widely available, generic options presentAvailabilityWidely available, generic options present
Hypersensitivity to doxycycline or other tetracyclinesContraindicationsHypersensitivity to doxycycline or other tetracyclines
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