Dulaglutide vs Semaglutide
DulaglutideSemaglutide
TrulicityBrand NamesOzempic, Rybelsus
GLP-1 receptor agonistDrug ClassGLP-1 receptor agonist
2014FDA ApprovalOzempic: 2017, Rybelsus: 2019
Type 2 diabetesIndicationsType 2 diabetes, chronic weight management (as Wegovy)
Mimics the incretin hormones, enhancing glucose-dependent insulin secretion, inhibiting glucagon secretion, slowing gastric emptyingMechanism of ActionSimilar to Dulaglutide
Subcutaneous injectionDosage FormsOzempic: Subcutaneous injection, Rybelsus: Oral tablet
0.75 mg or 1.5 mg once weeklyCommon DosagesOzempic: 0.5 mg or 1 mg once weekly, Rybelsus: 7 mg or 14 mg daily
Nausea, diarrhea, vomiting, abdominal pain, decreased appetiteSide EffectsNausea, vomiting, diarrhea, stomach pain, constipation
Category CPregnancy CategoryCategory C
May affect drugs needing gastric emptying like oral contraceptivesDrug InteractionsSimilar to Dulaglutide
Personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)ContraindicationsSimilar to Dulaglutide
Does not require meal timing adjustmentsConsiderationsRybelsus requires taking 30 minutes before first meal of the day
Once-weekly dosing makes it convenient for patientsBenefitsSemaglutide has shown greater efficacy in glucose control and weight loss in some studies
Widely availableAvailabilityWidely available
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