Gralise vs Gabapentin
Drug Class
Anticonvulsant, Neuropathic Pain AgentPrimary Indications
- Seizures (partial onset) - Neuropathic pain - Postherpetic neuralgia - Off-label: Anxiety, Migraine preventionMechanism of Action
Modulates calcium channels in the nervous system, reducing nerve pain signals.Dosage Forms
Immediate-release capsules, tablets, oral solutionCommon Dosages
- Neuropathy: 900–3600 mg/day (divided doses) - Seizures: 900–1800 mg/day (divided doses)Onset of Action
1–3 hours (immediate-release)Duration of Action
5–7 hours (requires multiple doses per day)Half-Life
5–7 hoursCommon Side Effects
- Drowsiness - Dizziness - Fatigue - Peripheral edemaSerious Side Effects
- Suicidal thoughts - Severe dizziness - Respiratory depression (high doses)Pregnancy Category
Category C (Use with caution)Controlled Substance
NoAddiction Potential
LowDrug Interactions
- CNS depressants (increased sedation) - Opioids (risk of respiratory depression)Monitoring Parameters
- Seizure control - Pain relief - Kidney functionWithdrawal Symptoms
- Anxiety - Insomnia - Nausea - Increased nerve painCoupon code
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What is the difference between Gralise and Gabapentin?
Gralise is an extended-release version of Gabapentin, designed for once-daily dosing, mainly for postherpetic neuralgia. Gabapentin is available in immediate-release forms and is used for seizures, nerve pain, and off-label conditions like anxiety and migraines.
Can I substitute Gralise with regular Gabapentin?
No, Gralise is not interchangeable with standard Gabapentin because it has a different absorption rate. Switching between them requires a doctor’s guidance.
Which medication is better for nerve pain?
Both work well for nerve pain, but Gralise is designed specifically for postherpetic neuralgia with once-daily dosing, while Gabapentin is more widely used and available at a lower cost.
Why is Gralise more expensive than Gabapentin?
Gralise is a brand-name extended-release formulation, while Gabapentin is available as a generic, making it much more affordable.
