Labetalol vs Metoprolol
LabetalolMetoprolol
Beta-blocker (non-selective with alpha-blocking properties)Drug ClassBeta-blocker (cardio-selective, primarily ?1 receptor)
Blocks beta-1, beta-2, and alpha-1 adrenergic receptors, reducing blood pressure by lowering heart rate, cardiac output, and peripheral resistance.Mechanism of ActionBlocks beta-1 adrenergic receptors, primarily affecting heart rate and cardiac output without significant alpha-blockade.
- Hypertension (including in pregnancy) - Hypertensive emergencies - Pheochromocytoma - Postural hypotension management (with monitoring)Indications- Hypertension - Angina - Post-myocardial infarction care - Atrial fibrillation/flutter - Heart failure (HF with reduced ejection fraction)
Oral and IVRoute of AdministrationOral and IV
- Oral: 100 mg twice daily (starting dose), max 2400 mg/day - IV: 20 mg initially, with incremental doses for hypertensive emergenciesDosage- Oral (Immediate Release): 50-100 mg daily in 1-2 divided doses - Oral (Extended Release): 25-200 mg once daily - IV: 5 mg every 2 minutes, max 15 mg
Oral: 20–60 minutes IV: Within 5 minutesOnset of ActionOral: 1 hour IV: Within minutes
8–12 hoursDuration of Action6–12 hours (Immediate Release); 24 hours (Extended Release)
Hepatic (via CYP enzymes, glucuronidation)MetabolismHepatic (primarily CYP2D6 enzyme)
Urine and fecesExcretionUrine (metabolites and unchanged drug)
Category C (used in pregnancy for hypertension management)Pregnancy CategoryCategory C (caution advised; limited data available)
- Dizziness - Fatigue - Orthostatic hypotension - Nausea - Bronchospasm in susceptible individualsCommon Side Effects- Fatigue - Dizziness - Bradycardia - Depression - Cold extremities
- Severe bradycardia - Heart block (greater than first-degree) - Cardiogenic shock - Asthma - Severe hepatic impairmentContraindications- Severe bradycardia - Heart block (greater than first-degree) - Cardiogenic shock - Severe asthma or bronchospasm
Monitor blood pressure and heart rate closely to avoid excessive hypotension. Caution in asthmatic patients due to beta-2 blockade.Special PrecautionsMonitor for worsening heart failure, bradycardia, and hypotension. Taper gradually to avoid withdrawal effects.
- Other antihypertensives: Additive hypotensive effects - Beta-agonists: Reduced efficacy - CYP enzyme inhibitors/inducers: Affects metabolismDrug Interactions- Other beta-blockers: Additive effects - CYP2D6 inhibitors: Increased plasma levels - NSAIDs: May reduce antihypertensive efficacy
Generally less expensive; varies by region and formulationCostWidely available and affordable; costs vary by formulation and region
Get Coupon Code
Enter your email Get your coupon code for more discount
Get Coupon Code
Enter your email Get your coupon code for more discount
Exclusive 30% OFF for New Customers!
