Liraglutide vs Semaglutide
SemaglutideLiraglutide
Ozempic, Wegovy, RybelsusBrand NamesVictoza, Saxenda
GLP-1 Receptor AgonistDrug ClassGLP-1 Receptor Agonist
Ozempic (2017 - Type 2 Diabetes), Wegovy (2021 - Weight Loss), Rybelsus (2019 - Type 2 Diabetes Oral)FDA ApprovalVictoza (2009 - Type 2 Diabetes), Saxenda (2014 - Weight Loss)
Subcutaneous injection (Ozempic, Wegovy), Oral tablet (Rybelsus)Administration RouteSubcutaneous injection
Weekly (Ozempic, Wegovy), Daily (Rybelsus)Dosing FrequencyDaily
Type 2 Diabetes, Chronic Weight Management (Wegovy),Cardiovascular Risk Reduction (Type 2 Diabetes)IndicationsType 2 Diabetes - Chronic Weight Management (Saxenda) - Cardiovascular Risk Reduction (Type 2 Diabetes)
0.25 mg/week (Titrated up to therapeutic dose)Starting Dose0.6 mg/day (Titrated up for diabetes or weight loss)
Ozempic: 0.5–2 mg/week,Wegovy: 2.4 mg/week, Rybelsus: 7–14 mg/dayMaintenance DoseVictoza: 1.2–1.8 mg/day - Saxenda: 3 mg/day
Superior A1c and weight reduction compared to liraglutideEffectivenessModerate A1c and weight reduction
Same as LiraglutideMechanism of ActionActivates GLP-1 receptors, increasing insulin secretion and slowing gastric emptying
~1.5–2.0%A1c Reduction~1.0–1.5%
~12–15% body weight (higher with Wegovy)Weight Loss~6–8% body weight (higher with Saxenda)
Nausea, vomiting, diarrhea, constipation, Headache, Injection site reactionsCommon Side EffectsNausea, vomiting, diarrhea, constipation - Headache - Injection site reactions
Pancreatitis, Thyroid tumors (animal studies),Gallbladder issues,Hypoglycemia (rare when used alone)Serious Side Effects- Pancreatitis - Thyroid tumors (animal studies) - Gallbladder issues (Saxenda) - Hypoglycemia (rare when used alone)
Same as Liraglutide - MEN2 syndrome - PregnancyContraindications- Personal/Family history of medullary thyroid carcinoma - MEN2 syndrome - Pregnancy
May delay absorption of oral medications - Same as LiraglutideInteractionsMay delay absorption of oral medications - Increased hypoglycemia risk with sulfonylureas or insulin
Prescription onlyAvailabilityPrescription only
Higher than liraglutide (depending on insurance coverage)CostModerate to high (depending on insurance coverage)
Weekly dosing increases convenience, More effective for weight lossClinical Advantages- Daily dosing may benefit adherence in specific populations - Approved for weight loss earlier (Saxenda)
Covered by most plans for diabetes; some restrictions for weight lossInsurance CoverageCovered by most plans for diabetes and weight loss
More potent in achieving glycemic and weight loss targetsSpecial NotesMay be preferred for patients with daily dosing habits
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