Loratadine vs Cetirizine
LoratadineCetirizine
Second-generation antihistamine
Drug Class
Second-generation antihistamine- Seasonal allergies (hay fever) - Chronic hives (urticaria) - Allergic rhinitis
Primary Indications
- Seasonal allergies (hay fever) - Chronic hives (urticaria) - Allergic rhinitisBlocks H1 histamine receptors to reduce allergy symptoms with minimal drowsiness
Mechanism of Action
Blocks H1 histamine receptors, but is slightly more sedating than LoratadineTablets, liquid, dissolvable tablets
Dosage Forms
Tablets, liquid, chewable tablets- Adults & children (6+ years): 10 mg once daily - Children (2–5 years): 5 mg once daily
Common Dosages
- Adults & children (6+ years): 10 mg once daily - Children (2–5 years): 2.5–5 mg once daily~1–3 hours
Onset of Action
~1 hour~24 hours
Duration of Action
~24 hours~8 hours
Half-Life
~7–10 hours- Dry mouth - Headache - Mild drowsiness (rare)
Common Side Effects
- Drowsiness - Fatigue - Dry mouthLow (non-drowsy)
Sedation Level
Moderate (may cause drowsiness in some people)- Rapid heartbeat (rare) - Allergic reactions
Serious Side Effects
- Severe drowsiness - Allergic reactionsCategory B (Safe in pregnancy)
Pregnancy Category
Category B (Safe in pregnancy)No
Controlled Substance
NoNone
Addiction Potential
None- Ketoconazole, erythromycin (increase drug levels) - Alcohol (mild interaction)
Drug Interactions
- Alcohol and sedatives (increase drowsiness)- Allergy symptom relief - Side effects like dry mouth
Monitoring Parameters
- Allergy symptom relief - Sedation levelNone
Withdrawal Symptoms
NoneAffordable, widely available as generic
Cost and Availability
Affordable, widely available as genericCoupon code
CMP30
Coupon code
Coupon code
CMP30
FAQ
Which is better for allergies: Loratadine or Cetirizine?
Both work well for allergies, but Loratadine is non-drowsy, making it better for daytime use, while Cetirizine is stronger but may cause drowsiness, making it ideal for severe allergies or nighttime relief.
Can I take Loratadine and Cetirizine together?
It is generally not recommended to take both together, as they work similarly and could increase the risk of side effects like dry mouth and drowsiness. Always consult a doctor before combining medications.
How long do Loratadine and Cetirizine last?
Both last for 24 hours, meaning they only need to be taken once daily for effective allergy relief.
Which antihistamine is safer for long-term use?
Both Loratadine and Cetirizine are considered safe for long-term daily use, but it’s best to consult a doctor if you need continuous allergy relief for months at a time.
