Nebivolol vs Metoprolol
Drug Class
Beta-1 selective blockerPrimary Indications
- Hypertension - Angina (chest pain) - Heart failure - Post-heart attack preventionMechanism of Action
Selectively blocks beta-1 receptors, reducing heart rate and blood pressure but lacks vasodilation effects.Dosage Forms
Oral tablets, extended-release tablets, IV injectionCommon Dosages
- Hypertension: 25–100 mg twice daily (IR), 25–200 mg once daily (ER) - Heart failure: 12.5–200 mg daily (ER)Onset of Action
1 hour (IR), 4–6 hours (ER)Duration of Action
IR: 6–12 hours ER: 24 hoursHalf-Life
IR: 3–7 hours ER: 7–9 hoursCommon Side Effects
- Fatigue - Dizziness - Slow heart rate - Cold hands/feetSerious Side Effects
- Bradycardia - Low blood pressure - Shortness of breath - DepressionPregnancy Category
Category C (Use with caution)Controlled Substance
NoAddiction Potential
NoneDrug Interactions
- Other beta-blockers - Calcium channel blockers - Digoxin (bradycardia risk)Monitoring Parameters
- Blood pressure - Heart rate - Symptoms of heart failureWithdrawal Symptoms
- Rebound hypertension - Chest pain - Increased heart rateCost and Availability
Affordable (generic available)Special Considerations
- Available in immediate and extended-release forms. - More widely studied for heart failure and post-heart attack care.Coupon code
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What is the main difference between Nebivolol and Metoprolol?
Nebivolol is a beta-1 selective blocker with vasodilation effects, improving blood flow. Metoprolol is a traditional beta-blocker that reduces heart rate and blood pressure but lacks vasodilation properties.
Which medication is better for high blood pressure?
Both lower blood pressure effectively, but Nebivolol’s vasodilation effect may benefit patients with circulatory issues. Metoprolol is more commonly prescribed for heart conditions.
Is Nebivolol or Metoprolol better for heart failure?
Metoprolol succinate (Toprol XL) is FDA-approved for heart failure and widely used. Nebivolol is sometimes used off-label but lacks the same extensive research.
Which medication has fewer side effects?
Nebivolol may cause less fatigue and dizziness due to its vasodilation effects, while Metoprolol can cause cold hands, slower heart rate, and fatigue more often.
