Nifedipine vs Amlodipine
NifedipineAmlodipine
Calcium Channel Blocker (Dihydropyridine)Drug ClassCalcium Channel Blocker (Dihydropyridine)
Inhibits calcium influx in vascular smooth muscle, causing vasodilation and reduced blood pressure.Mechanism of ActionInhibits calcium influx in vascular smooth muscle, causing sustained vasodilation and reduced blood pressure.
- Hypertension - Angina (chronic stable, variant) - Raynaud’s phenomenonPrimary Indications- Hypertension - Angina (chronic stable, variant) - Coronary artery disease
Capsules, extended-release tablets (10 mg, 20 mg, 30 mg, 60 mg, 90 mg)Dosage FormsTablets (2.5 mg, 5 mg, 10 mg)
20–30 minutes (Immediate release)Onset of Action6–12 hours
Liver (CYP3A4)MetabolismLiver (CYP3A4)
Urine (60–80%) and fecesExcretionUrine (10%) and feces (90%)
- Flushing - Dizziness - Headache - Swelling (edema) - Reflex tachycardiaCommon Side Effects- Swelling (edema) - Fatigue - Dizziness - Flushing
- Severe hypotension - Heart palpitations - Peripheral edema - Gingival hyperplasiaSerious Side Effects- Severe hypotension - Heart palpitations - Peripheral edema - Rare liver dysfunction
- Severe aortic stenosis - Hypersensitivity - Cardiogenic shockContraindications- Severe aortic stenosis - Hypersensitivity - Cardiogenic shock
- CYP3A4 inhibitors (e.g., grapefruit juice): Increase nifedipine levels - Beta-blockers: Additive hypotension - NSAIDs: Reduced antihypertensive effectDrug Interactions- CYP3A4 inhibitors (e.g., grapefruit juice): Increase amlodipine levels - Beta-blockers: Enhanced hypotensive effect
Category CPregnancy CategoryCategory C
Small amounts excreted in breast milk; caution advisedBreastfeedingLikely safe; consult a doctor
- Blood pressure - Heart rate - Signs of peripheral edemaMonitoring Parameters- Blood pressure - Signs of peripheral edema
- Rapid action for hypertensive emergencies (immediate release) - Effective for Raynaud\\\'s phenomenonBenefits- Longer-acting - Lower risk of reflex tachycardia - Better tolerated for chronic use
Generally affordable; available as genericCostGenerally affordable; available as generic
Get Coupon Code
Enter your email Get your coupon code for more discount
Get Coupon Code
Enter your email Get your coupon code for more discount
Exclusive 30% OFF for New Customers!
