Semaglutide vs Phentermine
SemaglutidePhentermine
GLP-1 receptor agonist
Drug Class
Sympathomimetic amine (Stimulant)- Type 2 diabetes (Ozempic, Rybelsus) - Weight management (Wegovy)
Primary Indications
- Short-term weight loss (in combination with diet and exercise)Mimics GLP-1 hormone, increasing insulin secretion, reducing appetite, and slowing gastric emptying.
Mechanism of Action
Stimulates the release of norepinephrine, suppressing appetite and increasing energy expenditure.Injection (Ozempic, Wegovy), Oral tablet (Rybelsus)
Dosage Forms
Oral tablets and capsules- Type 2 diabetes: 0.25–2 mg once weekly (Ozempic) - Weight loss: 2.4 mg once weekly (Wegovy)
Common Dosages
- 15–37.5 mg once daily, usually in the morning1–3 days for appetite suppression, weeks for blood sugar control
Onset of Action
Within hours~7 days (long half-life)
Duration of Action
~24 hours~7 days (for injection)
Half-Life
20 hours- Nausea - Vomiting - Diarrhea - Constipation - Decreased appetite
Common Side Effects
- Dry mouth - Increased heart rate - Insomnia - Nervousness - Constipation- Pancreatitis - Thyroid tumors (in animals) - Severe gastrointestinal issues
Serious Side Effects
- Hypertension - Heart palpitations - Psychological dependence - Risk of stroke or heart attackCategory C (Not recommended)
Pregnancy Category
Category X (Contraindicated in pregnancy)No
Controlled Substance
Schedule IVLow
Addiction Potential
High (stimulant-like properties)- Insulin and sulfonylureas (hypoglycemia risk) - Delayed absorption of oral drugs
Drug Interactions
- MAO inhibitors (risk of hypertensive crisis) - Other stimulants (increased heart risk)- Blood sugar levels - Weight loss progress - Gastrointestinal symptoms
Monitoring Parameters
- Blood pressure - Heart rate - Mood changes (risk of dependency)- Increased appetite - Blood sugar fluctuations
Withdrawal Symptoms
- Fatigue - Depression - Increased hunger- Can cause severe nausea, start with a low dose. - Not for Type 1 diabetes.
Special Considerations
- Short-term use only (few weeks recommended). - Not suitable for individuals with heart disease or high blood pressure.Coupon code
CMP30
Coupon code
Coupon code
CMP30
