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What is Imipramine used for?

Imipramine is used to treat depression. Imipramine helps improve mood and relieves other symptoms of depression by increasing the amount of certain natural substances (such as norepinephrine and serotonin) in the brain. It belongs to a group of drugs called tricyclic antidepressants.

Imipramine is also used along with other therapies for the treatment of nocturnal enuresis (night-time bedwetting) in children aged 6 years and older. Imipramine may also be used to treat other conditions as determined by your doctor.

What is the recommended dosage of Imipramine?

The dosage of Imipramine prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.

Take Imipramine by mouth with or without food.

What if you miss a dose of Imipramine?

If your physician has instructed or directed you to take Imipramine medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses to catch up for the missed dose.

What if you overdose on Imipramine?

Any medication taken in excess can have serious consequences. If you suspect an overdose of Imipramine, seek medical attention immediately.

Symptoms of overdose of Imipramine may include fast/irregular heartbeat, severe dizziness, drowsiness, confusion, fainting, hallucinations, seizures and breathing difficulties.

What other drugs could interact with Imipramine?

It may be noted that drugs other than those listed above may also interact with Imipramine.

Imipramine can interact with the following types of medicines: MAO inhibitors, heart rhythm medications, bronchodilators, Parkinson's disease medications, high blood pressure medications, anticoagulants, antihistamines, SSRI antidepressants, sleeping pills, thyroid medications and certain other antidepressants.

Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications (over-the-counter products) and dietary supplements like vitamins, minerals and herbal, which may increase the effect of Imipramine, so that the doctor can warn you of any possible drug interactions.

Do let your doctor know if you smoke, consume alcohol or caffeinated drinks, or use illegal drugs as these may interfere with the action of your medication. Make sure to inform your doctor of any medical conditions you may have, or any family history of medical problems. Do not start or stop using any medicine without consulting your doctor.

What are the side effects of Imipramine?

Like other medicines, Imipramine can cause some side effects. If they do occur, the side effects of Imipramine are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately.

It is pertinent to note that side effects of Imipramine cannot be anticipated. If any side effects of Imipramine develop or change in intensity, the doctor should be informed as soon as possible.

Imipramine can cause side effects such as dizziness, headache, nausea, vomiting, sleepiness, weakness, dry mouth, excessive sweating, constipation, weight changes, blurred vision, sexual dysfunction and increased or irregular heartbeat. This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are taking Imipramine.

What are the questions to ask your doctor before taking Imipramine?

Is it possible for me to take Imipramine with other drugs?
Should certain beverages, foods and other products be avoided when I take Imipramine?
What are the possible drug interactions of Imipramine?
How will Imipramine work in my body?
How should Imipramine be taken?
How to reduce the risk of Imipramine drug interactions and side effects?


  • As Imipramine may cause drowsiness, exercise caution when driving or operating any machinery.
  • Avoid alcoholic drink while taking Imipramine.
  • Avoid exposure to sunlight as Imipramine may make your skin sensitive to sunlight.
  • Inform your doctor if you are pregnant, planning a pregnancy, or if you are breastfeeding your baby.
  • Before using Imipramine, tell your doctor if you have an overactive thyroid gland, diabetes, breathing problems, urinary problems, liver or kidney problems, eye problems, eating disorders, or if you have had a recent heart attack.
  • The health and medical information provided here is intended to supplement and not substitute for the expertise and judgment of your physician, pharmacists or other health care professional. It should not be understood to indicate that the use of Imipramine is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.


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