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What is Leucovorin Calcium used for?

Leucovorin Calcium is used to prevent harmful effects of certain drugs (folic acid antagonists) such as methotrexate, trimethoprim, and pyrimethamine. It belongs to a class of medications called folic acid analogs. This medicine reduces the folic-acid-lowering side effects of methotrexate or similar medications by protecting healthy cells from their effects. It is also used to treat a condition known as megaloblastic anemia. This drug is used in combination with fluorouracil to treat cancer of the colon as well. This medicine may also be used to treat other conditions as determined by your doctor.

What is the recommended dosage of Leucovorin Calcium?

The dosage of Leucovorin Calcium prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.

Leucovorin Calcium can be taken with or without food.

What if you miss a dose of Leucovorin Calcium?

If your physician has instructed or directed you to take Leucovorin Calcium medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses unless otherwise directed.

What if you overdose on Leucovorin Calcium?

Any medication taken in excess can have serious consequences. If you suspect an overdose of Leucovorin Calcium, seek medical attention immediately.

What other drugs could interact with Leucovorin Calcium?

It may be noted that drugs other than those listed above may also interact with Leucovorin Calcium.

Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications, over-the-counter medicines that may increase the effect of Leucovorin Calcium, and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions.

Leucovorin Calcium can interact with certain seizure medications.

Do let your doctor know if you smoke, consume alcohol or caffeinated drinks, or use illegal drugs as these may interfere with the action of your medication. Make sure to inform your doctor of any medical conditions you may have, or any family history of medical problems. Do not start or stop using any medicine without consulting your doctor.

What are the side effects of Leucovorin Calcium?

Like other medicines, Leucovorin Calcium can cause some side effects. If they do occur, the side effects of Leucovorin Calcium are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately.

It is pertinent to note that side effects of Leucovorin Calcium cannot be anticipated. If any side effects of Leucovorin Calcium develop or change in intensity, the doctor should be informed as soon as possible.

Leucovorin Calcium can cause side effects such as diarrhea, itching, difficulty breathing, rash, and hives. This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are taking Leucovorin Calcium.

What are the questions to ask your doctor before taking Leucovorin Calcium?

Is it possible for me to take Leucovorin Calcium with other drugs?
Should certain beverages, foods and other products be avoided when I take Leucovorin Calcium?
What are the possible drug interactions of Leucovorin Calcium?
How will Leucovorin Calcium work in my body?
How should Leucovorin Calcium be taken?
How to reduce the risk of Leucovorin Calcium drug interactions and side effects?


The health and medical information provided here is intended to supplement and not substitute for the expertise and judgment of your physician, pharmacists or other health care professional. It should not be understood to indicate that the use of Leucovorin Calcium is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.


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