What is Rebamipide 100mg?
Rebamipide is a gastroprotective agent belonging to the class of anti-ulcer medications. It is manufactured by Macleods Pharmaceuticals and is available in a 100mg tablet formulation. Rebamipide works by supporting and strengthening the natural protective lining of the stomach (gastric mucosa), rather than primarily reducing acid secretion as some other anti-ulcer drugs do.
Active Ingredient and Drug Classification
Active Ingredient: Rebamipide
Drug Class: Gastric mucosal protective agent (mucoprotective / cytoprotective agent)
Dosage Strength: 100mg per tablet
Common Formulation: Oral tablet
Manufacturer Information
This product is manufactured by Macleods Pharmaceuticals, a pharmaceutical company that produces generic and branded medications. Information regarding manufacturing standards, batch testing, and quality certifications should be verified directly through official manufacturer documentation or regulatory filings.
Rebamipide Mechanism of Action
Rebamipide's mechanism of action is distinct from proton pump inhibitors (PPIs) or H2 receptor antagonists, as it does not primarily target acid suppression.
How Rebamipide Protects the Gastric Mucosa
Rebamipide is reported to work through several proposed mechanisms, including:
Stimulating prostaglandin synthesis in the gastric mucosa
Increasing mucus and bicarbonate secretion, which helps form a protective barrier over the stomach lining
Scavenging free radicals that may contribute to mucosal damage
Supporting the repair process of damaged gastric epithelial cells
Pharmacokinetics Overview
Pharmacokinetic details (absorption, metabolism, and elimination) can vary based on formulation and individual patient factors. Specific pharmacokinetic data should be referenced from the official prescribing information or regulatory drug monograph rather than general summaries.
Note: Mechanism of action descriptions are based on published pharmacological literature. Patients should refer to the product insert or consult a healthcare provider for complete pharmacological information.
Rebamipide Uses and Approved Indications
Primary Use in Gastric Ulcer Management
Rebamipide is used in the management of gastric ulcers, where it is intended to support mucosal healing and protect the stomach lining from further damage.
Use in Gastritis and Mucosal Protection
Rebamipide may also be used in cases of gastritis, where inflammation of the stomach lining requires mucosal protective therapy.
Other Reported Uses
Rebamipide has been studied in other contexts, such as dry eye conditions (in ophthalmic formulations) in some regions. This product page pertains specifically to the oral 100mg tablet formulation for gastric indications. Any use outside the approved indication for this specific product should be discussed with a healthcare provider.
Approved indications may vary by country and regulatory authority. Always refer to the locally approved prescribing information.
Dosage and Administration
General Dosage Information
Dosage should be determined by a licensed healthcare provider based on the patient's condition, medical history, and other individual factors. Typical reported dosing in clinical literature is 100mg taken orally, but exact frequency and duration must be confirmed through a prescription or medical consultation.
Administration Instructions
Rebamipide is generally taken orally, with or without food, as directed by a healthcare provider
Tablets should be swallowed whole with water unless otherwise instructed
Do not alter the dose without consulting a physician
Missed Dose
If a dose is missed, patients should follow the guidance provided by their prescribing physician or pharmacist rather than doubling the next dose.
Overdose
In case of suspected overdose, seek immediate medical attention or contact a poison control center.
Rebamipide Side Effects
As with any medication, Rebamipide may cause side effects in some individuals. Not everyone experiences side effects, and their frequency/severity can vary.
Commonly Reported Side Effects
Constipation
Diarrhea
Nausea
Abdominal discomfort
Headache
Less Common or Serious Side Effects
Allergic reactions (rash, itching, swelling)
Liver function abnormalities (reported in some cases)
Blood cell count changes (reported rarely in clinical literature)
Patients experiencing severe or persistent side effects should seek prompt medical attention.
Side Effects in Specific Populations
Elderly patients: May require closer monitoring due to age-related changes in drug metabolism
Patients with hepatic or renal impairment: Dose adjustment or additional monitoring may be necessary; consult a physician
Pregnant or breastfeeding individuals: See Contraindications and Precautions section below
This list is not exhaustive. Refer to the official package insert for a complete list of reported adverse effects.
Rebamipide Drug Interactions
Known Drug-to-Drug Interactions
Rebamipide's interaction profile should be evaluated by a healthcare provider or pharmacist, particularly if the patient is taking:
Other gastric acid-modifying medications
Anticoagulants or antiplatelet agents
Medications metabolized through similar hepatic pathways
Interactions with Food or Other Substances
Specific food or supplement interactions should be confirmed through official prescribing literature, as data may vary by formulation and region.
General Precaution
Always inform your healthcare provider of all medications, supplements, and herbal products being taken before starting Rebamipide to reduce the risk of interactions.
Contraindications and Precautions
Who Should Avoid Rebamipide
Individuals with known hypersensitivity to Rebamipide or any excipients in the formulation
Patients with specific contraindications noted in the official prescribing information
Use During Pregnancy and Breastfeeding
The safety of Rebamipide during pregnancy and breastfeeding should be evaluated on a case-by-case basis by a qualified healthcare provider. Data on use in these populations may be limited; a risk-benefit assessment by a physician is recommended.
Warnings for Patients with Pre-Existing Conditions
Patients with a history of liver disease, kidney disease, or blood disorders should disclose their full medical history to their prescribing physician before starting this medication.
Storage and Handling Instructions
Store at room temperature, away from direct sunlight and moisture, unless otherwise specified on the product label
Keep out of reach of children
Do not use after the expiration date printed on the packaging
Dispose of unused or expired medication according to local pharmaceutical disposal guidelines
Frequently Asked Questions (FAQ)
Is Rebamipide safe for long-term use?
Duration of use should be determined by a healthcare provider based on individual condition and response to treatment. Long-term use should be periodically reviewed by a physician.
Can Rebamipide be taken with other ulcer medications?
Combination therapy with other anti-ulcer medications (such as PPIs) may be prescribed in some cases, but this should only be done under medical supervision due to potential interactions.
What should I do if I experience side effects?
Discontinue use and contact a healthcare provider if side effects are severe, persistent, or concerning. Seek emergency care for signs of a serious allergic reaction.
Is a prescription required for Rebamipide 100mg?
Prescription requirements vary by country and regulatory jurisdiction. Check with a local pharmacy or regulatory authority for applicable rules.
Is the price inclusive of shipping?
Product pricing and shipping charges are generally shown separately, with shipping cost (or eligibility for free shipping) calculated based on order total and delivery location.
Medical Disclaimer
The information provided on this page is intended for general educational purposes only and does not constitute medical advice. It is not a substitute for professional consultation, diagnosis, or treatment provided by a licensed physician or pharmacist. Always seek the advice of a qualified healthcare provider before starting, stopping, or changing any medication. Never disregard professional medical advice or delay seeking it because of information read on this page.
International Drug Mart does not assume responsibility for decisions made based on the content of this page. Product availability, approved indications, and regulatory status may vary by country.