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What is Rifampin–Isoniazid–Pyrazinamide used for?

Rifampin–Isoniazid–Pyrazinamide is an antituberculosis medicine used to treat tuberculosis (TB). It is a combination of three antibiotics namely Rifampin, Isoniazid and Pyrazinamide, which work by killing the tuberculosis bacteria. This medicine may also be used to treat other conditions as determined by your doctor.

What is the recommended dosage of Rifampin–Isoniazid–Pyrazinamide?

The dosage of Rifampin–Isoniazid–Pyrazinamide prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.

Take Rifampin–Isoniazid–Pyrazinamide same time each day, on an empty stomach.

What if you miss a dose of Rifampin–Isoniazid–Pyrazinamide?

If your physician has instructed or directed you to take Rifampin–Isoniazid–Pyrazinamide medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses unless otherwise directed.

What if you overdose on Rifampin–Isoniazid–Pyrazinamide?

Any medication taken in excess can have serious consequences. If you suspect an overdose of Rifampin–Isoniazid–Pyrazinamide, seek medical attention immediately.

What other drugs could interact with Rifampin–Isoniazid–Pyrazinamide?

It may be noted that drugs other than those listed above may also interact with Rifampin–Isoniazid–Pyrazinamide.

Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications, over-the-counter medicines that may increase the effect of Rifampin–Isoniazid–Pyrazinamide, and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions.

Rifampin–Isoniazid–Pyrazinamide can interact with corticosteroids, antacids, and beta-blockers.

Do let your doctor know if you smoke, consume alcohol or caffeinated drinks, or use illegal drugs as these may interfere with the action of your medication. Make sure to inform your doctor of any medical conditions you may have, or any family history of medical problems. Do not start or stop using any medicine without consulting your doctor.

What are the side effects of Rifampin–Isoniazid–Pyrazinamide?

Like other medicines, Rifampin–Isoniazid–Pyrazinamide can cause some side effects. If they do occur, the side effects of Rifampin–Isoniazid–Pyrazinamide are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately.

It is pertinent to note that side effects of Rifampin–Isoniazid–Pyrazinamide cannot be anticipated. If any side effects of Rifampin–Isoniazid–Pyrazinamide develop or change in intensity, the doctor should be informed as soon as possible.

Rifampin–Isoniazid–Pyrazinamide can cause side effects such as nausea, vomiting, diarrhea, loss of appetite, anxiety, bone pain, cough, and headache. This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are taking Rifampin–Isoniazid–Pyrazinamide.

What are the questions to ask your doctor before taking Rifampin–Isoniazid–Pyrazinamide?

Is it possible for me to take Rifampin–Isoniazid–Pyrazinamide with other drugs?
Should certain beverages, foods and other products be avoided when I take Rifampin–Isoniazid–Pyrazinamide?
What are the possible drug interactions of Rifampin–Isoniazid–Pyrazinamide?
How will Rifampin–Isoniazid–Pyrazinamide work in my body?
How should Rifampin–Isoniazid–Pyrazinamide be taken?
How to reduce the risk of Rifampin–Isoniazid–Pyrazinamide drug interactions and side effects?


The health and medical information provided here is intended to supplement and not substitute for the expertise and judgment of your physician, pharmacists or other health care professional. It should not be understood to indicate that the use of Rifampin–Isoniazid–Pyrazinamide is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.


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