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What does Sulfamethoxazole–Trimethoprim treat?

Sulfamethoxazole–Trimethoprim is a combination drug that is very effective in treating a wide range of bacterial infections such as ear infections, urinary tract infections, traveler's diarrhea, respiratory infections, bronchitis and pneumocystis carinii pneumonia. This works by stopping the bacteria from growing further. Your physician may use this to treat other ailments based on their discretion.

Dosage Instructions

Follow the Sulfamethoxazole–Trimethoprim dosage prescribed by your physician. The dosage could vary based on individual patient requirements. Always follow your physician’s instructions or go by the directions on the prescription drug label. Always take it with a full glass of water.

Missed a dose?

Take it immediately once you remember. In case, this time is closer to the next dosage, skip it and get back to the prescribed schedule. Never take a double dose.


Don’t waste any time and seek immediate medical attention. Overdose symptoms can include headache, drowsiness, loss of appetite, mood changes, dizziness, nausea, vomiting, stomach pain, diarrhea and fever.

Drug Interactions

Drug interactions must be considered before starting to take any kind of drug. Drug interactions might happen either when Sulfamethoxazole–Trimethoprim is taken along with another drug or with particular foods. To prevent any kind of negative interaction, make sure you inform your doctor of any drugs you are taking including non-prescription medication, OTCs, health supplements like vitamins, minerals, herbal medicine and so on which may interfere with the effect of Sulfamethoxazole–Trimethoprim.

It may interact with: 

  • Amantadine Hcl 
  • Lisinopril 
  • Cyclosporine 
  • Digoxin 

It may also interact with anti-diabetic medications, diuretics, blood thinners, ACE inhibitors, live vaccines, tricyclic antidepressants and oral contraceptive pills. This is not an exhaustive list though.

Appraise your doctor of any medical conditions that you are suffering from and your family history of medical ailments. You must specially appraise the doctor of conditions such as asthma, kidney or liver disease, Diabetes, folic acid deficiency and AIDS. If you are pregnant or planning to become pregnant, you must let your doctor know. Avoid using this drug if you are breastfeeding. You must also stay away from prolonged sun exposure. It’s important that you do not stop or start taking any medicine without the consent of your physician.

Possible Side Effects

Sulfamethoxazole–Trimethoprim might have some side effects but it’s not possible to anticipate them. It does not have any major side effects and the minor ones that may occur are temporary. In rare cases, there might be major side effects and immediate medical attention must be sought.

Some of the side effects are dizziness, muscle weakness, insomnia, low blood sugar, nausea, vomiting, joint pain, diarrhea, loss of appetite, neck stiffness and headache. This is not an exhaustive list though. In case, there is a change in intensity of side effects or if any new side effects develop, make sure you consult your doctor.

What to ask your doctor before you start on Sulfamethoxazole–Trimethoprim

  • Can I take Sulfamethoxazole–Trimethoprim along with other drugs? 
  • Are there certain foods, beverages and products to be avoided while on Sulfamethoxazole–Trimethoprim? 
  • What is the dosage of Sulfamethoxazole–Trimethoprim to be consumed?
  •  How should I use Sulfamethoxazole–Trimethoprim?
  •  How will Sulfamethoxazole–Trimethoprim work on my body?
  •  How can the drug interactions and side effects of Sulfamethoxazole–Trimethoprim be minimized or completely avoided?


The health and medical information that we have provided are meant to supplement and not substitute the advice of your physician, pharmacists or other health care professionals. This does not suggest that usage of Sulfamethoxazole–Trimethoprim is safe, appropriate or effective for you. Always ensure that you take this or any other drug only after consulting your physician.


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