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What is Xylometazoline used for?

Xylometazoline is a topical nasal decongestant used to temporarily relieve congestion in the blocked nose caused by the common cold, flu and nasal allergies such as hay fever (allergic rhinitis).

Xylometazoline, available as nasal drops, belongs to a group of drugs called nasal decongestants. Xylometazoline works by narrowing the blood vessels in the lining of the nose and sinuses, which decreases the blood flow in the nose. This reduces swelling and clears the blocked and stuffy nose, thereby allowing you to breathe easily.

Xylometazoline may also be used to treat other conditions as determined by your doctor.

What is the recommended dosage of Xylometazoline?

The dosage of Xylometazoline prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.

Xylometazoline nasal drops should be used in the nose only and it should not be taken by mouth.

To apply the Xylometazoline nasal drops, tilt your head back and insert 2 or 3 drops in each nostril. It is not recommended to use the drops for more than 3 days in a row. Longer use of this drops can lead to rebound congestion. Inform your doctor if your problem persists even after 3 days of using the Xylometazoline nasal drops.

What if you miss a dose of Xylometazoline?

If your physician has instructed or directed you to use Xylometazoline medication in a regular schedule and you have missed a dose of this medicine, use it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses to catch up for the missed dose.

What if you overdose on Xylometazoline?

Any medication used in excess can have serious consequences. If you suspect an overdose of Xylometazoline, seek medical attention immediately. Overdose symptoms of Xylometazoline nasal drops may include dizziness, drowsiness, slow heartbeat and sweating.

What other drug(s) could interact with Xylometazoline?

It may be noted that drugs other than those listed above may also interact with Xylometazoline.

Avoid taking monoamine oxidase (MAO) inhibitors for the last 14 days before treatment with Xylometazoline nasal drops. MAO inhibitors include linezolid, isocarboxazid, methylene blue, phenelzine, tranylcypromine, moclobemide, procarbazine, rasagiline and selegiline.

Following are the other types of medicines that may interact with Xylometazoline: high blood pressure medications, tricyclic antidepressants, phenothiazines, appetite suppressants and other decongestants.

Usually drug interactions occur when it is used with another drug or with food. Before you use a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications (over-the-counter products) and dietary supplements like vitamins, minerals and herbal, which may increase the effect of Xylometazoline, so that the doctor can warn you of any possible drug interactions.

Do let your doctor know if you smoke, consume alcohol or caffeinated drinks, or use illegal drugs as these may interfere with the action of your medication. Make sure to inform your doctor of any medical conditions you may have, or any family history of medical problems. Do not start or stop using any medicine without consulting your doctor.

What are the side effects of Xylometazoline?

Like other medicines, Xylometazoline can cause some side effects. If they do occur, the side effects of Xylometazoline are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately.

It is pertinent to note that side effects of Xylometazoline cannot be anticipated. If any side effects of Xylometazoline develop or change in intensity, the doctor should be informed as soon as possible.

Xylometazoline can cause side effects such as temporary dryness, irritation, tingling, stinging or burning sensation in the nose and sneezing. This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are using Xylometazoline.

What are the questions to ask your doctor before taking Xylometazoline?

Is it possible for me to use Xylometazoline with other drugs?
Should certain beverages, foods and other products be avoided when I use Xylometazoline?
What are the possible drug interactions of Xylometazoline?
How will Xylometazoline work in my body?
How should Xylometazoline be used?
How to reduce the risk of Xylometazoline drug interactions and side effects?

What other important information should you know about Xylometazoline?

Before using Xylometazoline nasal drops, make sure to tell your doctor if you have hypersensitivity to Xylometazoline drug, or if you have enlarged prostate, narrow angle glaucoma, heart disease, high blood pressure, diabetes, liver/kidney disease and thyroid problems. Also, tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding.

  • Store Xylometazoline nasal drops at room temperature away from heat and moisture.
  • Do not share this nasal drops with others.
  • Do not let the tip of the nasal drops container to touch the inside of the nose.
  • Keep Xylometazoline nasal drops out of the reach of children.


The health and medical information provided here is intended to supplement and not substitute for the expertise and judgment of your physician, pharmacists or other health care professional. It should not be understood to indicate that the use of Xylometazoline is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.


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